TOB1 and SMAD6

Number of citations of the paper that reports this interaction (PubMedID 12782279)
19

Data Source:
HPRD (two hybrid)

		TOB1	SMAD6
Description		transducer of ERBB2, 1	SMAD family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm CCR4-NOT Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Golgi Apparatus Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Transcription Corepressor Activity SH3/SH2 Adaptor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Transforming Growth Factor Beta Receptor, Inhibitory Cytoplasmic Mediator Activity Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Type I Activin Receptor Binding
	Biological Process	Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nucleic Acid-templated Transcription	Ureteric Bud Development Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Pulmonary Valve Morphogenesis Ventricular Septum Development Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Zygotic Specification Of Dorsal/ventral Axis Negative Regulation Of Cell Proliferation Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Cell-substrate Adhesion Response To Lipopolysaccharide Response To Laminar Fluid Shear Stress Aorta Development Negative Regulation Of Apoptotic Process Response To Estrogen Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways			Signaling by BMP RUNX2 regulates bone development
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Asthma ( 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Carpal tunnel syndrome ( 30833571) Dental caries (decayed and filled deciduous teeth) ( 31533690) Height ( 31562340) Lung cancer (smoking interaction) ( 24658283) Severe aortic features in Marfan syndrome ( 30087447) Subcutaneous adipose tissue ( 22589738) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9	16 interacting genes: BMPR1B HOXC8 MAP3K7 MAPK6 RNF111 RPS6KA5 RUNX2 SMAD1 SMAD7 SMURF1 SMURF2 STAMBP STRAP TAB1 TGFBR1 TOB1
Entrez ID		10140	4091
HPRD ID		09273	04240
Ensembl ID		ENSG00000141232	ENSG00000137834
Uniprot IDs		P50616	O43541
PDB IDs		2D5R 2Z15 5CI8 5CI9
Enriched GO Terms of Interacting Partners?
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