PDIA6 and CEP250

		PDIA6	CEP250
Description		protein disulfide isomerase family A member 6	centrosomal protein 250
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Exosome	Photoreceptor Outer Segment Photoreceptor Inner Segment Centrosome Centriole Microtubule Organizing Center Cytosol Protein-containing Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Peptide Disulfide Oxidoreductase Activity	Protein Binding Protein C-terminus Binding Protein Kinase Binding Protein Domain Specific Binding
	Biological Process	Protein Folding IRE1-mediated Unfolded Protein Response Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Oxidation-reduction Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Centriole-centriole Cohesion Regulation Of Centriole-centriole Cohesion Protein Localization To Organelle Detection Of Light Stimulus Involved In Visual Perception Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome Non-motile Cilium Assembly
Pathways		XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Height ( 25429064 18391951) Ulcerative colitis ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: ATP13A2 CASP8 CEP250 CLN8 CSNK2A1 LGALS9 MTNR1A MTNR1B NPC2 SLC2A4 SUMO4 TRIM14 UBE3A VKORC1	14 interacting genes: APP ATF7IP FAM83D FRMD5 ITCH KAT2B KCNG3 MYL9 NEK2 PDIA6 PHF20 PLEKHA5 TTI1 YWHAG
Entrez ID		10130	11190
HPRD ID		07504	09877
Ensembl ID		ENSG00000143870	ENSG00000126001
Uniprot IDs		A0A384NPU5 Q15084	Q9BV73
PDB IDs		1X5D 3VWW 3W8J 4EF0 4GWR
Enriched GO Terms of Interacting Partners?
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