DNAL4 and CAMK2D

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DNAL4	CAMK2D
Description		dynein axonemal light chain 4	calcium/calmodulin dependent protein kinase II delta
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Plasma Membrane Cilium Dynein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Neuron Projection
	Molecular Function	Microtubule Motor Activity Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Inhibitor Activity Titin Binding Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Microtubule-based Movement Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	Regulation Of Cell Growth Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Regulation Of Heart Contraction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endoplasmic Reticulum Calcium Ion Homeostasis Protein Autophosphorylation Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Localization Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cellular Response To Heat Regulation Of Histone Deacetylase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Retrograde neurotrophin signalling	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants
Drugs			[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE
Diseases
GWAS			Atrial fibrillation ( 30061737 29892015) Chronic lymphocytic leukemia ( 28165464 24292274) Chronotype ( 30696823) Hip circumference adjusted for BMI ( 28552196) Ischemic stroke (small-vessel) ( 29531354) Non-small cell lung cancer (survival) ( 25145502) P wave duration ( 28794112) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		9 interacting genes: CAMK2D DYNLL2 FHL5 GNA14 GPBP1 KRTAP10-3 NOTCH2NLA SCTR TRIM54	28 interacting genes: ACTN2 ARL2BP BANP CAMK2B CD5 CREM DNAL4 EPHA10 ERCC8 FAM171B FKBP1B FNDC3B FXR2 GRIN2B HNMT IFNGR2 MOAP1 MRPL11 RPS18 RPS4X SMARCB1 SPATA24 SRPK1 STAT1 TNPO2 TTC5 VIM WASF3
Entrez ID		10126	817
HPRD ID		13239	09653
Ensembl ID		ENSG00000100246	ENSG00000145349
Uniprot IDs		O96015	D6R938 E9PBG7 E9PF82 Q13557
PDB IDs			2VN9 2W2C 2WEL 3GP2 5VLO 6AYW
Enriched GO Terms of Interacting Partners?
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