ACTR3 and SHARPIN

Number of citations of the paper that reports this interaction (PubMedID 28775156)
2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ACTR3	SHARPIN
Description		actin related protein 3	SHANK associated RH domain interactor
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Arp2/3 Protein Complex Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Actin Cortical Patch Site Of Double-strand Break Extracellular Exosome	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Cell Junction Dendrite LUBAC Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Spindle Localization Cilium Assembly Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Interferon-gamma	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Metabolite levels ( 23823483) Systolic blood pressure in sickle cell anemia ( 24058526)	Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		16 interacting genes: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN HCLS1 JUND SHARPIN UBE3A WASF1 WASF2 WASF3 WASL	16 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 PPIL3 SHANK1 SHANK2 TRAF1 TXN2 UBC YOD1
Entrez ID		10096	81858
HPRD ID		05024	15463
Ensembl ID		ENSG00000115091	ENSG00000179526
Uniprot IDs		A0A024RAI1 B4DXW1 P61158	Q6PJD5 Q9H0F6
PDB IDs			4EMO 5X0W
Enriched GO Terms of Interacting Partners?
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