ARPC3 and HOXA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ARPC3	HOXA3
Description		actin related protein 2/3 complex subunit 3	homeobox A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Filamentous Actin Site Of Double-strand Break Growth Cone Leading Edge Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding HMG Box Domain Binding
	Biological Process	Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Cellular Response To Nerve Growth Factor Stimulus	Angiogenesis Blood Vessel Remodeling Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Specification Of Animal Organ Position Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Animal Organ Formation Embryonic Skeletal System Morphogenesis Cartilage Development Parathyroid Gland Development Positive Regulation Of Receptor Binding
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)	Chronic venous disease ( 28374850) Diastolic blood pressure ( 27618448) Hypertension ( 27618448 30487518) Mean arterial pressure ( 27618448) Monocyte count ( 27863252) Pulse pressure ( 30487518) Systolic blood pressure ( 28135244 27618448 30487518)
Interacting Genes		21 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CDKN2B CETP EFTUD2 GOLGA2 HOXA3 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 PRMT1 RPS4X THNSL2 WAS WASF2 WASHC4 WASL	9 interacting genes: ALX4 ARPC3 POT1 PWP1 SEC23B SOX10 TERF1 TINF2 ZDHHC17
Entrez ID		10094	3200
HPRD ID		09175	00842
Ensembl ID		ENSG00000111229	ENSG00000105997
Uniprot IDs		O15145	A0A024RA33 A4D182 B3KPN8 O43365
PDB IDs
Enriched GO Terms of Interacting Partners?
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