TANK and MARCHF5

Number of citations of the paper that reports this interaction (PubMedID 21625535)
26

Data Source:
BioGRID (enzymatic study)

		TANK	MARCHF5
Description		TRAF family member associated NFKB activator	membrane associated ring-CH-type finger 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding GTPase Binding
	Biological Process	Proteolysis Cellular Response To DNA Damage Stimulus Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Viral Process TRIF-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity	Protein Polyubiquitination Protein Autoubiquitination Protein Localization To Mitochondrion Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission Negative Regulation Of Cell Aging
Pathways		TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Alcohol consumption ( 27911795) Chronotype ( 30696823) Dietary macronutrient intake ( 23372041) Educational attainment ( 25201988) Educational attainment (years of education) ( 23722424) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Smoking status (ever vs never smokers) ( 30643258) Subcutaneous adipose tissue ( 22589738) Tourette syndrome ( 30818990) Treatment response for severe sepsis ( 22310353) Weight ( 31647587)
Interacting Genes		31 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCHF5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 USP7 ZC3H12A	19 interacting genes: AKTIP CREB3 FATE1 FIS1 FUNDC1 MAP1B MFN2 SOD1 TANK UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN
Entrez ID		10010	54708
HPRD ID		04870	07909
Ensembl ID		ENSG00000136560	ENSG00000198060
Uniprot IDs		B2R7S3 Q6NW12 Q92844	Q9NX47
PDB IDs		1KZZ 1L0A 5H10
Enriched GO Terms of Interacting Partners?
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