LITAF

Description		lipopolysaccharide induced TNF factor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Intracellular Membrane-bounded Organelle Cytoplasmic Side Of Early Endosome Membrane Cytoplasmic Side Of Late Endosome Membrane Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding WW Domain Binding
	Biological Process	Regulation Of Cytokine Production Regulation Of Transcription By RNA Polymerase II Aging Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of NIK/NF-kappaB Signaling
Pathways
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Colorectal or endometrial cancer ( 26621817) Crohn's disease ( 28067908) Gallstone disease ( 30504769) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908 23128233) QT interval ( 23166209 30679814 29213071 24952745 19305408 19305409) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		15 interacting genes: ATXN1 BAG3 CALCOCO2 COMT HGS ITCH NEDD4 OPTN PLOD2 RADIL REEP6 SMAD2 STAM2 STAT6 UBQLN1
Entrez ID		9516
HPRD ID		10354
Ensembl ID		ENSG00000189067
Uniprot IDs		Q99732
PDB IDs
Enriched GO Terms of Interacting Partners?
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