CDH1 and PTPN14

Number of citations of the paper that reports this interaction (PMID 12808048)
19

Data Source:
HPRD (in vivo)

		CDH1	PTPN14
Gene Name		cadherin 1, type 1, E-cadherin (epithelial)	protein tyrosine phosphatase, non-receptor type 14
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Aggresome Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Cell Junction Node Of Ranvier Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Axon Terminus Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytoskeleton
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Protein Domain Specific Binding Ankyrin Binding GTPase Activating Protein Binding Gamma-catenin Binding Cell Adhesion Molecule Binding	Transcription Cofactor Activity Protein Tyrosine Phosphatase Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Trophectodermal Cell Differentiation Epithelial Cell Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Sensory Perception Of Sound Response To Toxic Substance Single Organismal Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Protein Metabolic Process Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neuron Projection Development Regulation Of Water Loss Via Skin Cell Junction Assembly Adherens Junction Organization Response To Drug Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Epithelial Cell Proliferation Regulation Of Immune Response Protein Homooligomerization Intestinal Epithelial Cell Development Salivary Gland Cavitation Regulation Of Branching Involved In Salivary Gland Morphogenesis Tight Junction Assembly Cellular Response To Amino Acid Stimulus Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Development Regulation Of Protein Localization To Cell Surface Regulation Of Neuron Migration	Lymphangiogenesis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Dephosphorylation Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Export From Nucleus
Pathways		Cell junction organization Apoptotic cleavage of cellular proteins Adherens junctions interactions Apoptotic execution phase Degradation of the extracellular matrix Apoptotic cleavage of cell adhesion proteins Cell-cell junction organization Programmed Cell Death Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Colorectal cancer ( 19011631) Ulcerative colitis ( 19915572)
Protein-Protein Interactions		55 interactors: ACTR3 ANAPC1 ANAPC11 ANAPC4 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC16 CDC23 CDC26 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBB2IP EZR FER FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP MAD2L2 MDM2 NDRG1 NEDD9 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 TACC3 UCHL3 VCL YES1	6 interactors: CDH1 CTNNA2 CTNNB1 JUP TJP1 YWHAG
Entrez ID		999	5784
HPRD ID		01885	04402
Ensembl ID		ENSG00000039068	ENSG00000152104
Uniprot IDs		P12830 Q9UII8	A8K6H6 Q15678
PDB IDs		1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y	2BZL
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Adhesion Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Chromosome Segregation Mitotic Spindle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Chromosome Segregation Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Anatomical Structure Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein K11-linked Ubiquitination Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Proteolysis Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Negative Regulation Of Chromosome Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Catabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process	Cellular Response To Indole-3-methanol Cell Junction Assembly Cell-cell Junction Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Adherens Junction Organization Cell-cell Junction Assembly Cellular Response To Organonitrogen Compound Single Organismal Cell-cell Adhesion Regulation Of Cell Differentiation Regulation Of Cell Fate Specification Regulation Of Protein Localization To Cell Surface Epithelial Cell Development Establishment Of Endothelial Barrier Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Localization Positive Regulation Of Intracellular Transport Response To Organonitrogen Compound Membrane Organization Regulation Of Cell Fate Commitment Epithelial Cell-cell Adhesion Apoptotic Process Regulation Of Wnt Signaling Pathway Blastocyst Formation Adherens Junction Assembly Endothelial Cell Development Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Epithelial Cell Morphogenesis Multicellular Organismal Development Response To Organic Substance Anatomical Structure Development Cell Adhesion Cellular Response To Organic Cyclic Compound Regulation Of Morphogenesis Of A Branching Structure Protein Oligomerization Regulation Of Intracellular Transport Endothelial Cell Differentiation Cellular Protein Localization Developmental Process Establishment Of Protein Localization To Plasma Membrane In Utero Embryonic Development Response To Drug Positive Regulation Of Muscle Cell Differentiation Endothelium Development Epithelial Cell Differentiation Organelle Organization
Tagcloud ?		alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	aberrant activators cooperatively decipher effectors exerting fate great hippo kibra last1 lats1 mesenchymal morphogenesis mst pivotal ppxy profound regulations rescue rescues sequestration ste20 summary taz terminus upstream ww yap
Tagcloud (Difference) ?		alleles atm brca1 brca2 brip1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	aberrant activators cooperatively decipher effectors exerting fate great hippo kibra last1 lats1 mesenchymal morphogenesis mst pivotal ppxy profound regulations rescue rescues sequestration ste20 summary taz terminus upstream ww yap
Tagcloud (Intersection) ?