FARP2 and UBE2G2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FARP2	UBE2G2
Gene Name		FERM, RhoGEF and pleckstrin domain protein 2	ubiquitin-conjugating enzyme E2G 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Extrinsic Component Of Membrane	Endoplasmic Reticulum Cytosol
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Cytoskeletal Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cell Adhesion Axon Guidance Neuron Remodeling Rac Protein Signal Transduction Osteoclast Differentiation Actin Cytoskeleton Reorganization Positive Regulation Of Rac GTPase Activity Regulation Of Integrin Activation Semaphorin-plexin Signaling Pathway Podosome Assembly	Ubiquitin-dependent Protein Catabolic Process Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Axon guidance Semaphorin interactions SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 20062064) Prostate cancer ( 23535732)
Protein-Protein Interactions		4 interactors: PDZK1 SRC UBE2G2 YWHAG	37 interactors: AMFR ARL14 BIRC8 CBL CNNM3 CPOX CUL9 FARP2 HBS1L HERPUD1 KDM2A KIAA0368 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 PARK2 POLR3F RBX1 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		9855	7327
HPRD ID		16885	04387
Ensembl ID		ENSG00000006607	ENSG00000184787
Uniprot IDs		O94887	P60604
PDB IDs			2CYX 2KLY 2LXP 3H8K 4LAD
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Protein Localization Membrane Organization Cellular Response To Progesterone Stimulus Regulation Of Cellular Localization Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Transport Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Response To Insulin Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Podosome Assembly Cellular Response To Peptide Positive Regulation Of Protein Transport Regulation Of Caveolin-mediated Endocytosis Osteoclast Development Negative Regulation Of Protein Oligomerization Positive Regulation Of Organelle Organization Regulation Of Integrin Activation Carnitine Transport Regulation Of Early Endosome To Late Endosome Transport Regulation Of Cellular Component Organization Transcytosis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Signal Complex Assembly Stress Fiber Assembly Response To Peptide Negative Regulation Of Anoikis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Response To Drug Uterus Development Intracellular Estrogen Receptor Signaling Pathway Regulation Of Anoikis Response To Acidic PH Quaternary Ammonium Group Transport Regulation Of Mitochondrial Depolarization Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Focal Adhesion Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of Apoptotic Process Response To Platelet-derived Growth Factor	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Catabolic Process Proteolysis Cellular Protein Metabolic Process Cellular Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Cellular Response To Topologically Incorrect Protein Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Regulation Of Mitochondrial Fusion Protein Autoubiquitination Response To Stimulus Response To Unfolded Protein Regulation Of Protein Stability Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?			alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive e3 elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring ubiquitin
Tagcloud (Difference) ?			alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive e3 elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring ubiquitin
Tagcloud (Intersection) ?