USP6NL and ACTN4

Number of citations of the paper that reports this interaction (PMID 15152255)
60

Data Source:
HPRD (in vivo, in vitro)

		USP6NL	ACTN4
Gene Name		USP6 N-terminal like	actinin, alpha 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cell-cell Junction Focal Adhesion Z Disc Ribonucleoprotein Complex Cortical Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Neuron Projection Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Rab GTPase Activator Activity Rab GTPase Binding	Nucleoside Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Poly(A) RNA Binding Protein N-terminus Binding Actin Filament Binding
	Biological Process	Golgi Organization Virion Assembly Positive Regulation Of Rab GTPase Activity Retrograde Transport, Plasma Membrane To Golgi Plasma Membrane To Endosome Transport Regulation Of Cilium Assembly Regulation Of Golgi Organization	Response To Hypoxia Platelet Degranulation Blood Coagulation Protein Transport Platelet Activation Positive Regulation Of Sodium:proton Antiporter Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Component Movement Tight Junction Assembly Protein Localization To Tight Junction Regulation Of Nucleic Acid-templated Transcription
Pathways			Response to elevated platelet cytosolic Ca2+ Nephrin interactions Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Heart rate ( 23583979)
Protein-Protein Interactions		6 interactors: ACTA1 ACTN4 APP EPS8 GRB2 RAB5A	43 interactors: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 ESR1 GSN HDAC7 INO80 ITGB1 KPNA2 LRRC7 MAGI1 MAPK7 MEF2A MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTPN11 PTPN6 RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 STAT1 TJP1 TRIM3 TXN UCHL5 USP6NL VDR
Entrez ID		9712	81
HPRD ID		08957	05222
Ensembl ID		ENSG00000148429
Uniprot IDs		Q92738	O43707
PDB IDs			1WLX 1YDI 2R0O
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Actin Crosslink Formation Platelet Activation Response To Wounding Ras Protein Signal Transduction Cellular Component Assembly Actin Filament Organization Receptor Internalization Regulation Of Cellular Component Size Response To Abiotic Stimulus Actin Filament Bundle Assembly Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Receptor Metabolic Process Vesicle-mediated Transport Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Small GTPase Mediated Signal Transduction Adult Locomotory Behavior Actin Filament-based Process Endocytosis Cell Activation Cellular Response To Stimulus Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction Cell Growth Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway Adult Behavior ERBB Signaling Pathway Collateral Sprouting In Absence Of Injury Protein Localization To Tight Junction Receptor Internalization Involved In Canonical Wnt Signaling Pathway Actin Polymerization-dependent Cell Motility Regulation Of Endosome Size Positive Regulation Of Pinocytosis Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Positive Regulation Of Sodium:proton Antiporter Activity Intracellular Receptor Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Collateral Sprouting Axon Midline Choice Point Recognition Leukocyte Migration Locomotory Behavior	Cellular Response To Organic Substance Response To Organic Substance Negative Regulation Of Signaling Response To Stress Developmental Process Cellular Response To Interferon-gamma Response To Interferon-gamma Negative Regulation Of Signal Transduction Regulation Of Cell Death Response To Abiotic Stimulus Defense Response Cellular Response To Lipid Regulation Of Signaling Regulation Of Apoptotic Process Signal Transduction Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Assembly Signaling Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Lipid Multicellular Organismal Development Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Cellular Process Response To Hormone Abortive Mitotic Cell Cycle System Development Mitotic Cell Cycle Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Tagcloud ?			1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?			1beta actin actinin blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically nphs1 p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?