ATP6V1G1 and BCL2L11

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ATP6V1G1	BCL2L11
Gene Name		ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	BCL2-like 11 (apoptosis facilitator)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Extracellular Vesicular Exosome	Mitochondrial Outer Membrane Cytosol Microtubule Endomembrane System Extrinsic Component Of Membrane BIM-BCL-xl Complex BIM-BCL-2 Complex
	Molecular Function	Hydrogen-exporting ATPase Activity, Phosphorylative Mechanism ATPase Binding	Protein Binding Microtubule Binding
	Biological Process	Cellular Iron Ion Homeostasis Insulin Receptor Signaling Pathway Transferrin Transport Interaction With Host Transmembrane Transport Phagosome Maturation Hydrogen Ion Transmembrane Transport	In Utero Embryonic Development B Cell Homeostasis B Cell Apoptotic Process Kidney Development Myeloid Cell Homeostasis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell-matrix Adhesion Spermatogenesis Brain Development Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mammary Gland Development Positive Regulation Of Protein Homooligomerization Response To Endoplasmic Reticulum Stress Tube Formation Odontogenesis Of Dentin-containing Tooth T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ear Development Positive Regulation Of Cell Cycle Regulation Of Organ Growth Neurotrophin TRK Receptor Signaling Pathway Developmental Pigmentation Regulation Of Developmental Pigmentation Spleen Development Thymus Development Post-embryonic Organ Morphogenesis Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Thymocyte Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Phagosomal maturation (early endosomal stage) Iron uptake and transport Latent infection of Homo sapiens with Mycobacterium tuberculosis Transferrin endocytosis and recycling Insulin receptor recycling Signaling by Insulin receptor	Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Activation of BIM and translocation to mitochondria NRAGE signals death through JNK Programmed Cell Death Activation of BH3-only proteins p75 NTR receptor-mediated signalling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461) Dehydroepiandrosterone sulphate levels ( 21533175) Primary sclerosing cholangitis ( 21151127)
Protein-Protein Interactions		8 interactors: AP2B1 APP ATP6V1E1 ATP6V1E2 BCL2L11 GOLGA2 LDOC1 MAGEA6	26 interactors: AKT1 APP ATP6V1G1 AURKB BCL2 BCL2A1 BCL2L1 BCL2L2 BTK DYNLL1 DYNLL2 FEM1C FGL1 GNB2L1 GTF2I MAGEA11 MAPK10 MAPK8 MAPK9 MCL1 MEX3D RIOK3 SMARCB1 TRIM2 VDAC1 YWHAB
Entrez ID		9550	10018
HPRD ID		06294	04828
Ensembl ID			ENSG00000153094
Uniprot IDs		O75348	O43521
PDB IDs			1F95 2K7W 2NL9 2V6Q 2VM6 2WH6 2YQ6 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4B4S
Enriched GO Terms of Interacting Partners?		Interaction With Host Transition Metal Ion Homeostasis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Transferrin Transport Phagosome Maturation Enzyme Linked Receptor Protein Signaling Pathway ATP Hydrolysis Coupled Proton Transport Cellular Metal Ion Homeostasis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Iron Ion Transport Cellular Cation Homeostasis Cellular Iron Ion Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Homeostatic Process Synaptic Growth At Neuromuscular Junction Ion Homeostasis Iron Ion Homeostasis Collateral Sprouting In Absence Of Injury Positive Regulation Of Peptidase Activity Regulation Of Protein Binding Insulin Receptor Signaling Pathway Cellular Homeostasis Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process By Virus Cell Surface Receptor Signaling Pathway Hydrogen Ion Transmembrane Transport Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Fibroblast Apoptotic Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Axon Choice Point Recognition Thymocyte Apoptotic Process B Cell Apoptotic Process Post-embryonic Organ Morphogenesis Chemical Homeostasis Proton Transport Neurotrophin Signaling Pathway Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Cellular Process Regulating Host Cell Cycle In Response To Virus Neuron Remodeling Positive Regulation Of Protein Homooligomerization Regulation Of Binding Positive Regulation Of Cell Cycle	Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Mitochondrion Organization Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Death Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand JUN Phosphorylation Intracellular Signal Transduction Apoptotic Mitochondrial Changes Regulation Of Signal Transduction Response To Radiation Positive Regulation Of Signal Transduction Response To Light Stimulus Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Stress Positive Regulation Of Intracellular Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Response To UV Regulation Of Establishment Of Protein Localization Fc Receptor Signaling Pathway Negative Regulation Of Cell Death Immune Response-regulating Signaling Pathway Regulation Of Neuron Death Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Defense Response Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Anoikis
Tagcloud ?			akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?			akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?