GGPS1 and ATOX1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GGPS1	ATOX1
Gene Name		geranylgeranyl diphosphate synthase 1	antioxidant 1 copper chaperone
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Dimethylallyltranstransferase Activity Farnesyltranstransferase Activity Geranyltranstransferase Activity Metal Ion Binding	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding
	Biological Process	Cholesterol Biosynthetic Process Isoprenoid Metabolic Process Geranyl Diphosphate Biosynthetic Process Geranylgeranyl Diphosphate Biosynthetic Process Small Molecule Metabolic Process Farnesyl Diphosphate Biosynthetic Process	Response To Reactive Oxygen Species Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress Intracellular Copper Ion Transport Copper Ion Transmembrane Transport
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Cholesterol biosynthesis Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP)	Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: ATOX1	6 interactors: ATP7A ATP7B C21orf2 FAM118A FKBP4 GGPS1
Entrez ID		9453	475
HPRD ID		06099	03779
Ensembl ID		ENSG00000152904	ENSG00000177556
Uniprot IDs		O95749	O00244
PDB IDs		2Q80	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX
Enriched GO Terms of Interacting Partners?		Intracellular Copper Ion Transport Copper Ion Transmembrane Transport Cellular Copper Ion Homeostasis Copper Ion Homeostasis Copper Ion Transport Transition Metal Ion Homeostasis Response To Reactive Oxygen Species	Copper Ion Transport Copper Ion Export Copper Ion Transmembrane Transport Copper Ion Import Cellular Copper Ion Homeostasis Copper Ion Homeostasis Response To Copper Ion Lactation Gland Development Body Fluid Secretion Elastin Biosynthetic Process Steroid Hormone Receptor Complex Assembly Plasma Membrane Copper Ion Transport Geranylgeranyl Diphosphate Biosynthetic Process Transition Metal Ion Homeostasis Geranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process Metal Ion Transport Mammary Gland Development Elastin Metabolic Process Detoxification Of Copper Ion Response To Iron(III) Ion Sequestering Of Calcium Ion Epinephrine Metabolic Process Intracellular Copper Ion Transport Farnesyl Diphosphate Metabolic Process Cation Transport Norepinephrine Biosynthetic Process Negative Regulation Of Metalloenzyme Activity Elastic Fiber Assembly Positive Regulation Of Metalloenzyme Activity Response To Metal Ion Regulation Of Oxidative Phosphorylation Sequestering Of Metal Ion Tyrosine Metabolic Process Pyramidal Neuron Development Pyramidal Neuron Differentiation Norepinephrine Metabolic Process Cellular Metal Ion Homeostasis Negative Regulation Of Microtubule Polymerization Cellular Zinc Ion Homeostasis Cerebellar Purkinje Cell Differentiation Serotonin Metabolic Process Cellular Cation Homeostasis Extracellular Matrix Assembly Cellular Ion Homeostasis Zinc Ion Homeostasis Cerebellar Purkinje Cell Layer Morphogenesis Ion Transport Metal Ion Homeostasis
Tagcloud ?			accumulated affects allowing chains chaperones chelated cisplatin compartments copper cu decays elucidation embryonic emission exist fibroblast hct nuclei nucleus optimizing owing positron radionuclide radiopharmaceuticals tomography traffic transport transporting upregulating
Tagcloud (Difference) ?			accumulated affects allowing chains chaperones chelated cisplatin compartments copper cu decays elucidation embryonic emission exist fibroblast hct nuclei nucleus optimizing owing positron radionuclide radiopharmaceuticals tomography traffic transport transporting upregulating
Tagcloud (Intersection) ?