ZFYVE9 and FAM46A

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		ZFYVE9	FAM46A
Gene Name		zinc finger, FYVE domain containing 9	family with sequence similarity 46, member A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Early Endosome Membrane
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Serine-type Peptidase Activity Metal Ion Binding	Poly(A) RNA Binding
	Biological Process	Proteolysis Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Regulation Of Gene Expression Regulation Of Blood Coagulation
Pathways
Drugs
Diseases
GWAS			Breast cancer ( 22976474) Corneal structure ( 23291589) Height ( 20881960 23563607)
Protein-Protein Interactions		38 interactors: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBB2IP ETS2 FAM46A FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPG20 ST7 SUMF2 SUPT5H SVEP1 TGFBR1 TGFBR2 UBC UBXN11 ZMYND8	16 interactors: ATXN1 BAG6 BCCIP CD93 COL4A2 DYNC1H1 EGLN2 HDLBP HTRA1 KEAP1 NR2F2 PSG3 RNF14 SPINT1 TBX4 ZFYVE9
Entrez ID		9372	55603
HPRD ID		04782	13311
Ensembl ID		ENSG00000157077	ENSG00000112773
Uniprot IDs		O95405	Q96IP4
PDB IDs		1DEV 1MK2 4BKW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Common-partner SMAD Protein Phosphorylation Cell Cycle Trachea Formation Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Embryonic Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Embryonic Cranial Skeleton Morphogenesis Cellular Response To Organic Substance Response To Organic Substance Photoperiodism Entrainment Of Circadian Clock Embryonic Skeletal System Development Lens Development In Camera-type Eye Cell Cycle Process Regulation Of Growth Signal Transduction Trachea Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Embryonic Foregut Morphogenesis Regulation Of Gene Expression Foregut Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Lung Development Negative Regulation Of Growth Negative Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Respiratory Tube Development Glycogen Metabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Skeletal System Morphogenesis Tube Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Death	Embryo Development Placenta Blood Vessel Development Intracellular Receptor Signaling Pathway Blood Vessel Development Vasculature Development Lung Development Respiratory Tube Development Radial Pattern Formation Respiratory System Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Anatomical Structure Development Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiovascular System Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Transcription, DNA-templated Blood Vessel Morphogenesis Dentinogenesis Proteasomal Ubiquitin-independent Protein Catabolic Process Embryonic Placenta Development Response To Estradiol RNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Tissue Development In Utero Embryonic Development Neuroendocrine Cell Differentiation Tail-anchored Membrane Protein Insertion Into ER Membrane Epithelium Development
Tagcloud ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Difference) ?		calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel ppp2r4 reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Intersection) ?