COPS2 and IP6K1

Number of citations of the paper that reports this interaction (PMID 25349427)
0

Data Source:
BioGRID (pull down)

		COPS2	IP6K1
Gene Name		COP9 signalosome subunit 2	inositol hexakisphosphate kinase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm COP9 Signalosome	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Transcription Corepressor Activity Signal Transducer Activity Protein Binding	Inositol Hexakisphosphate 5-kinase Activity ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Cell Proliferation Cullin Deneddylation Neuron Differentiation Skeletal Muscle Cell Differentiation	Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Phosphorylation
Pathways			Synthesis of IPs in the nucleus Synthesis of pyrophosphates in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		39 interactors: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL1 CUL4A CUL5 DDB1 EP300 GFER GPS1 HIST1H3A HIST1H4A ING1 ING2 IP6K1 IRF8 JUN MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 PSMD4 RARA RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR	6 interactors: CACNA1A COPS2 DDB1 EXOSC7 GPS1 RAB3IL1
Entrez ID		9318	9807
HPRD ID		05146	07379
Ensembl ID		ENSG00000166200	ENSG00000176095
Uniprot IDs		P61201 Q59EL2	Q92551
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Cullin Deneddylation Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Removal Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Hormone-mediated Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Metabolic Process Signal Transduction DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Signaling Cellular Response To Steroid Hormone Stimulus Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Regulation Of Protein Deacetylation Cellular Response To Lipid Metabolic Process Cell Communication Intracellular Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Cell Death Gene Expression	Cullin Deneddylation Protein Deneddylation Cerebellar Molecular Layer Development Protein Modification By Small Protein Removal Vestibular Nucleus Development Positive Regulation By Virus Of Viral Protein Levels In Host Cell Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission UV-damage Excision Repair Positive Regulation Of Viral Release From Host Cell Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Pons Development Histone H2A Monoubiquitination Cerebellar Purkinje Cell Differentiation Histone H2A Ubiquitination Cerebellar Purkinje Cell Layer Morphogenesis Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Histone Monoubiquitination Reflex Positive Regulation Of Viral Genome Replication Regulation Of Viral Release From Host Cell Behavioral Response To Pain Neuromuscular Synaptic Transmission
Tagcloud ?			2c acetyl adapt begun conversely cues demethylase depend dissociation epigenetic epigenetically fundamental h3k9 h3k9me3 hexakisphosphate influences inositol ip7 jmjd2c jumonji knockout lysine modifications pyrophosphate pyrophosphates repression rnai translates trimethyl
Tagcloud (Difference) ?			2c acetyl adapt begun conversely cues demethylase depend dissociation epigenetic epigenetically fundamental h3k9 h3k9me3 hexakisphosphate influences inositol ip7 jmjd2c jumonji knockout lysine modifications pyrophosphate pyrophosphates repression rnai translates trimethyl
Tagcloud (Intersection) ?