YTHDC1 and ADAMTS4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		YTHDC1	ADAMTS4
Gene Name		YTH domain containing 1	ADAM metallopeptidase with thrombospondin type 1 motif, 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Body	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding Poly(A) RNA Binding	Protease Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	MRNA Splice Site Selection	Skeletal System Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Defense Response To Bacterium
Pathways			Post-translational protein modification O-glycosylation of TSR domain-containing proteins Degradation of the extracellular matrix O-linked glycosylation
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		34 interactors: ABL1 ADAMTS4 CFH CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 LAMC3 LAMTOR5 LZTS2 MPRIP PLG PROSER2 RBMY1F SDCBP2 SEPT10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51	11 interactors: ACAN BCAN FN1 FURIN HP MT2A SERPINA1 SERPINA3 SRPX2 YTHDC1 ZBTB16
Entrez ID		91746	9507
HPRD ID		11689	04853
Ensembl ID		ENSG00000083896
Uniprot IDs		J3QR07 Q96MU7	O75173
PDB IDs		2YUD	2RJP 3B2Z
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing Peptidyl-tyrosine Autophosphorylation Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Protein Autophosphorylation Regulation Of Cell-cell Adhesion RNA Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Wnt Signaling Pathway Gene Expression Viral Process Innate Immune Response Regulation Of Cell Proliferation Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Cell Adhesion Anatomical Structure Development Leukocyte Migration Regulation Of Canonical Wnt Signaling Pathway Immune Response Regulation Of RNA Metabolic Process Regulation Of Intracellular Transport Cytoplasmic Transport Defense Response Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Localization Activated T Cell Proliferation Phagocytosis Positive Regulation Of Viral Genome Replication Regulation Of Neuron Death Heterocycle Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Aromatic Compound Metabolic Process Nuclear Export Regulation Of T Cell Activation Nucleus Organization Regulation Of Gene Expression Developmental Process Regulation Of Nitrogen Compound Metabolic Process Antigen Receptor-mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Cellular Process Golgi To Plasma Membrane Transport	Acute-phase Response Acute Inflammatory Response Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Peptidase Activity Inflammatory Response Pathogenesis Regulation Of Proteolysis Defense Response Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Proteolysis Platelet Degranulation Negative Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Response To Methanol Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Nerve Growth Factor Production Response To Triglyceride Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Response To Inorganic Substance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Secretion By Cell Cell Adhesion Negative Regulation Of Cellular Metabolic Process Response To Chromate Cellular Response To Erythropoietin Nerve Growth Factor Processing Calcium-independent Cell-matrix Adhesion Negative Regulation Of Hydrogen Peroxide Metabolic Process Skeletal System Development Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cellular Response To Interleukin-3 Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Serine-type Endopeptidase Activity Male Germ-line Stem Cell Asymmetric Division Secretion Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Negative Regulation Of Serine-type Peptidase Activity
Tagcloud ?			affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover
Tagcloud (Difference) ?			affymetrix continues crabp2 depleted differentiating directs driving exons intergenic introns luciferase master mineralization networks occupancy osteoblast osteoblastogenesis osteoblasts osteogenesis partitioned peaks performing regions remodelers runx2 termination throughput tnfrsf19 turnover
Tagcloud (Intersection) ?