CREB3L1 and CREM

Number of citations of the paper that reports this interaction (PMID 12805554)
98

Data Source:
HPRD (in vitro)

		CREB3L1	CREM
Gene Name		cAMP responsive element binding protein 3-like 1	cAMP responsive element modulator
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding CAMP Response Element Binding Sequence-specific DNA Binding	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Glycosphingolipid Metabolic Process Signal Transduction Multicellular Organismal Development Spermatogenesis Cell Differentiation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To CAMP
Pathways
Drugs
Diseases
GWAS			Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		23 interactors: C5 CREB3 CREB3L3 CREM DDIT3 FAM3C FBXW7 FXYD6 GPR25 JAGN1 MFSD5 NRM PGRMC1 PRKAB2 RUNX1T1 SLC30A8 SLC35B4 TMEM147 TMEM218 TMEM234 TSPO UBA1 UBE2D3	29 interactors: ATF1 ATXN1 CAMK2D CAMK2G CASP8AP2 CD34 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 EMP3 FHL5 GSK3A GSK3B HDAC1 KCNIP3 MAPK3 PIAS3 PRKACA PRKCA SP100 SPI1 TAF4 TBP UBE2I
Entrez ID		90993	1390
HPRD ID		16751	00444
Ensembl ID		ENSG00000157613	ENSG00000095794
Uniprot IDs		B2RA75 Q96BA8	Q03060
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Response To Organic Substance ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Cellular Response To Stress Response To Stress Response To Unfolded Protein Regulation Of Lipid Biosynthetic Process Regulation Of Ion Homeostasis Response To Endoplasmic Reticulum Stress Ion Transport Negative Regulation Of Cell Cycle Signaling Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Cell Communication Modification-dependent Protein Catabolic Process Regulation Of Cytokine Production Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Negative Regulation Of SREBP Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway UDP-xylose Transport Molybdate Ion Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Protein Catabolic Process Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Signal Transduction Proteasomal Protein Catabolic Process Inorganic Anion Transport Protein Catabolic Process Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Macrophage Chemotaxis UDP-N-acetylglucosamine Transport Release From Viral Latency Regulation Of Transcription Involved In Anterior/posterior Axis Specification UDP-N-acetylglucosamine Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Neuron Death Anion Transport Cellular Response To Stimulus Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Neutrophil Differentiation Response To Vitamin B1	Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Response To Heat Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Cardiac Muscle Hypertrophy Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transcription, DNA-templated Response To Growth Factor Cell Death Death Cellular Protein Modification Process Regulation Of Metabolic Process Cell Cycle RNA Biosynthetic Process Regulation Of Cellular Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Gene Expression Peptidyl-serine Phosphorylation Hypermethylation Of CpG Island Peptidyl-amino Acid Modification Nucleobase-containing Compound Metabolic Process Apoptotic Process Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway Programmed Cell Death Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Macromolecule Biosynthetic Process Cellular Response To Heat Heterocycle Metabolic Process
Tagcloud ?		aggressive bladder candidate clearly colony downregulation hence highlights htra3 hypermethylation immunohistochemical interestingly invasive j82 mediates nuclei potentially predominately proposed public putative pyrosequencing set suppression suppressor tgf tissues verified	27mer abp activin artefact artefactual basally bluescript bouin crna cystatin digoxigenin distinguishable inhibin ix leptotene promotor propria protamine pyronin rbs riboprobes seminiferous sgp spermatocytes sulphated t7 trichloroacetic tubules viii
Tagcloud (Difference) ?		aggressive bladder candidate clearly colony downregulation hence highlights htra3 hypermethylation immunohistochemical interestingly invasive j82 mediates nuclei potentially predominately proposed public putative pyrosequencing set suppression suppressor tgf tissues verified	27mer abp activin artefact artefactual basally bluescript bouin crna cystatin digoxigenin distinguishable inhibin ix leptotene promotor propria protamine pyronin rbs riboprobes seminiferous sgp spermatocytes sulphated t7 trichloroacetic tubules viii
Tagcloud (Intersection) ?