USP14 and USP21

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP14	USP21
Gene Name		ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	ubiquitin specific peptidase 21
Image
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Membrane-bounded Vesicle Synapse Extracellular Vesicular Exosome	Cellular_component Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding TRNA Guanylyltransferase Activity Proteasome Binding	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Synaptic Transmission Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: COPS5 CXCR4 FANCC UBC USP15 USP21 USP28	43 interactors: ATXN3 BAP1 CBL CBLC DTX3 ESPL1 EXOSC10 HIST2H2AA3 ISG15 JOSD1 KRT40 LRSAM1 OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 STAMBP TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 YOD1
Entrez ID		9097	27005
HPRD ID		06279	05291
Ensembl ID		ENSG00000101557	ENSG00000143258
Uniprot IDs		B7Z4N8 P54578	Q9UK80
PDB IDs		2AYN 2AYO	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Protein Modification By Small Protein Removal Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Histone Deubiquitination Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Proteolysis Cellular Macromolecule Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction By P53 Class Mediator DNA Repair Regulation Of MAPK Cascade Histone H2B Conserved C-terminal Lysine Deubiquitination Activation Of MAPK Activity Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Modification Process DNA Damage Checkpoint Catabolic Process Exosomal Secretion Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Viral Life Cycle Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Positive Regulation Of MAP Kinase Activity Cell Cycle Checkpoint Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Germ Cell Development Programmed Cell Death Cullin Deneddylation Cell Death Death Activation Of Protein Kinase Activity Monoubiquitinated Protein Deubiquitination DNA Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Abiotic Stimulus	Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Protein K48-linked Deubiquitination Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone Deubiquitination Metabolic Process Monoubiquitinated Protein Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Cellular Process Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell
Tagcloud ?		20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb2 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated	4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing
Tagcloud (Difference) ?		20s abstaining accumulated affecting antagonizes apigenin biochemistry bortezomib chymotrypsin depolarization desired deubiquitinase e6ap fda flavonoid mechanistically pc preferentially proteasomal proteasome psma5 psmb1 psmb2 psmb5 selectively subtle trihydroxyflavone trypsin ubiquitinated	4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing
Tagcloud (Intersection) ?