UNC119 and PAFAH1B3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UNC119	PAFAH1B3
Gene Name		unc-119 homolog (C. elegans)	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Lipid Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis	Lipid Metabolic Process Spermatogenesis Nervous System Development Brain Development Lipid Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24	33 interactors: BRD7 C14orf1 CCDC90B CHMP7 COPS6 CRMP1 DDX24 ECH1 EEF1A1 GAPDH GBP2 GDF9 HSPH1 IGSF21 LNX1 LRIF1 MED31 PAFAH1B1 PAFAH1B2 PLEKHM1 RBM48 SDCBP2 SETDB1 SUMO4 TERF1 TERF2IP TLE1 TP53 TUBB2A UNC119 XRCC6 ZBTB16 ZHX1
Entrez ID		9094	5050
HPRD ID		04927	04354
Ensembl ID		ENSG00000109103	ENSG00000079462
Uniprot IDs		Q13432	Q15102
PDB IDs		3GQQ 3RBQ 4GOJ 4GOK
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance RNA Biosynthetic Process Regulation Of Chromosome Organization Telomere Maintenance Negative Regulation Of Gene Expression Cell Division Negative Regulation Of DNA Metabolic Process RNA Metabolic Process Cell Separation After Cytokinesis Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Telomere Maintenance Negative Regulation Of Transcription, DNA-templated RNA-dependent DNA Replication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Response To X-ray Cellular Macromolecule Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Mitotic Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Fibroblast Proliferation Biosynthetic Process Macromolecule Biosynthetic Process Response To Salt Stress Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Stem Cell Division Chromosome Organization Mitotic Cell Cycle Process Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Negative Regulation Of DNA Recombination At Telomere Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Gene Expression Mitotic Cell Cycle Neuron Apoptotic Process Cellular Response To Ionizing Radiation Negative Regulation Of Transcription From RNA Polymerase II Promoter 'de Novo' Posttranslational Protein Folding Metabolic Process
Tagcloud ?			abpp acetylhydrolase acyl aided campaign carbamate carbamoylation cherry endeavored fluopol hits house hts hydrolase hydrolases medchem ml256 mudpit oxidatively phospholipids picked pla2g7 scaffold sid tunable
Tagcloud (Difference) ?			abpp acetylhydrolase acyl aided campaign carbamate carbamoylation cherry endeavored fluopol hits house hts hydrolase hydrolases medchem ml256 mudpit oxidatively phospholipids picked pla2g7 scaffold sid tunable
Tagcloud (Intersection) ?