CCNT1 and AFF4

Number of citations of the paper that reports this interaction (PMID 12065898)
17

Data Source:
HPRD (in vivo)

		CCNT1	AFF4
Gene Name		cyclin T1	AF4/FMR2 family, member 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Positive Transcription Elongation Factor Complex B	Nucleus Nucleoplasm Nucleolus Mitochondrion Transcription Elongation Factor Complex Transcriptionally Active Chromatin
	Molecular Function	DNA Binding Chromatin Binding Protein Binding SnRNA Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Viral Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Cell Division	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Spermatid Development
Pathways		Loss of Function of TGFBR2 in Cancer Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway HIV Transcription Elongation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer Interactions of Tat with host cellular proteins TGFBR1 KD Mutants in Cancer Pausing and recovery of Tat-mediated HIV elongation Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AFF4 AHR BRD4 CDK9 CTD ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MBP MDFIC MYC NCOA2 NUFIP1 PML POLR2A PURA RN7SK SKP2 SUPT5H	9 interactors: AP2B1 CCNT1 CDK9 GOLGA2 MLLT1 MTUS2 SIAH1 SPP1 TRAF2
Entrez ID		904	27125
HPRD ID		03938	09187
Ensembl ID		ENSG00000129315	ENSG00000072364
Uniprot IDs		A8K4M5 A9XU13 O60563	Q9UHB7
PDB IDs		2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY	4IMY
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Positive Regulation Of Viral Transcription Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Viral Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Viral Transcription Regulation Of Viral Process Positive Regulation Of Viral Process Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-templated Transcription, Initiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Cell Cycle Transcription Elongation From RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription, Elongation Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity 7-methylguanosine MRNA Capping Positive Regulation Of Metabolic Process	Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Replication Fork Arrest Response To Organic Substance Viral Process Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Growth Factor Stimulus Chemotaxis Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Collateral Sprouting Negative Regulation Of Glial Cell Apoptotic Process Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Axon Regeneration Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Binding Positive Regulation Of Protein Homodimerization Activity Regulation Of Protein Metabolic Process Cellular Response To Nitric Oxide Regulation Of Protein Phosphorylation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Positive Regulation Of Bone Resorption Regulation Of Axon Regeneration Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Adhesion Regulation Of Protein Homodimerization Activity Locomotion Axon Guidance Cellular Response To Reactive Nitrogen Species Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Arrest Cell Cycle
Tagcloud ?			af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes tefb
Tagcloud (Difference) ?			af4 af9 arise cofactor complexes cyclint1 defined definitive dot1 eaf1 eaf2 ell elongation functionally fusion immortalization interactions k79 leukemias leukemogenesis mechanistic methyltransferase mll overlapping partners reconstitution reside subcomplexes tefb
Tagcloud (Intersection) ?