WASF1 and IL12A

Number of citations of the paper that reports this interaction (PMID 16862120)
85

Data Source:
HPRD (in vitro)

		WASF1	IL12A
Gene Name		WAS protein family, member 1	interleukin 12A
Image
Gene Ontology Annotations	Cellular Component	Cytoskeleton Actin Cytoskeleton Cell Junction SCAR Complex Synapse	Extracellular Space Cytoplasm Interleukin-12 Complex
	Molecular Function	Actin Binding Protein Binding Protein Complex Binding Rac GTPase Binding	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity
	Biological Process	Protein Complex Assembly Movement Of Cell Or Subcellular Component Rac Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Defense Response To Protozoan Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Major depressive disorder ( 23377640) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 19458352 21399635 20639880)
Protein-Protein Interactions		28 interactors: ABI1 ABL1 ACTB ACTG1 ACTR2 BAD BAIAP2 BRK1 CDC42 CDK5 CRK CXCL8 CYFIP2 DNMBP FYN GNAI1 GRB2 IFT20 IL12A NCK1 NCKAP1 PFN1 PRKAR2A PSTPIP1 RAC1 SORBS2 SRGAP3 TRIP10	5 interactors: CD28 CXCL8 EBI3 IL12B WASF1
Entrez ID		8936	3592
HPRD ID		05434	01193
Ensembl ID		ENSG00000112290	ENSG00000168811
Uniprot IDs		Q92558	E9PGR3 O60595 P29459
PDB IDs		3P8C	1F45 3HMX
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Endocytosis Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Vesicle-mediated Transport Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Defense Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Actin Cytoskeleton Organization Actin Filament-based Process Immune System Process Response To Stress Signaling Blood Coagulation Cell Communication Hemostasis Movement Of Cell Or Subcellular Component Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Transport Cellular Response To Stimulus Regulation Of Body Fluid Levels Locomotion Wound Healing Cell Projection Morphogenesis Cell Part Morphogenesis Cytoskeleton Organization Cell Projection Organization Response To Stimulus Response To Wounding Axonogenesis Axon Guidance Ephrin Receptor Signaling Pathway Axon Development	Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cytokine Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion T-helper 1 Type Immune Response Cytokine Metabolic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Regulation Of Immune System Process Positive Regulation Of Interferon-gamma Production Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Cell Activation Leukocyte Activation Regulation Of Viral Genome Replication Regulation Of Cytokine Production Regulation Of Defense Response To Virus Regulation Of Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Cell Activation Response To Cytokine Immune System Process Cytokine Production Regulation Of Protein Metabolic Process Cell Cycle Arrest Positive Regulation Of Adaptive Immune Response Positive Regulation Of Cell Proliferation Interferon-gamma Biosynthetic Process Cellular Response To Lipopolysaccharide T Cell Differentiation Regulation Of Viral Process Cellular Response To Molecule Of Bacterial Origin
Tagcloud ?			allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios
Tagcloud (Difference) ?			allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios
Tagcloud (Intersection) ?