CCNA1 and CKS1B

Number of citations of the paper that reports this interaction (PMID 19786724)
4

Data Source:
BioGRID (pull down)

		CCNA1	CKS1B
Gene Name		cyclin A1	CDC28 protein kinase regulatory subunit 1B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Microtubule Cytoskeleton	Nucleoplasm
	Molecular Function	Protein Binding Protein Kinase Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Male Meiosis I Spermatogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Proliferation Cell Division
Pathways		Cellular Senescence G2/M Transition Cyclin E associated events during G1/S transition Orc1 removal from chromatin Cyclin A/B1 associated events during G2/M transition G2 Phase G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes S Phase Regulation of APC/C activators between G1/S and early anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins SCF(Skp2)-mediated degradation of p27/p21 Orc1 removal from chromatin Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases	Cyclin D associated events in G1 SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1 Phase Cyclin E associated events during G1/S transition SCF(Skp2)-mediated degradation of p27/p21 S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		34 interactors: ARID2 BRCA1 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GNB2L1 GPS2 HIST1H1A HIST1H1B HIST1H2BA INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6	34 interactors: ARID5A CCNA1 CCNA2 CCNB2 CDC27 CDC37 CDK1 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CUL1 DUSP1 HSP90AA1 IKZF1 KIAA0368 KRTAP10-9 KRTAP5-9 LDHB MEOX1 MIPOL1 PSMD9 REL ROPN1 SEPT3 SKP1 SKP2 SPERT SSBP1 SUMO1P1 TCF4 TRIM27 XIAP
Entrez ID		8900	1163
HPRD ID		04946	00299
Ensembl ID		ENSG00000133101	ENSG00000173207
Uniprot IDs		P78396	P61024 Q5T178
PDB IDs			1BUH 1DKS 1DKT 2ASS 2AST
Enriched GO Terms of Interacting Partners?		Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Kinase Activity Chromosome Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Organelle Organization Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression DNA Damage Checkpoint Positive Regulation Of Metabolic Process DNA Replication Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression DNA Conformation Change Cell Division Mitotic Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Cell Division Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Checkpoint Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Mitotic DNA Integrity Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Kinase Activity Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts	axis biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse
Tagcloud (Difference) ?		asparaginase clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts	biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse
Tagcloud (Intersection) ?		axis