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CCNA2 and SP1
Number of citations of the paper that reports this interaction (PMID
11598016
)
19
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology, pull down)
CCNA2
SP1
Gene Name
cyclin A2
Sp1 transcription factor
Image
Gene Ontology Annotations
Cellular Component
Female Pronucleus
Male Pronucleus
Nucleus
Nucleoplasm
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Protein-DNA Complex
Molecular Function
Protein Binding
Protein Kinase Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Histone Acetyltransferase Binding
Enhancer Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
BHLH Transcription Factor Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Metal Ion Binding
HMG Box Domain Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Mitotic Nuclear Division
Mitotic G2 DNA Damage Checkpoint
Ras Protein Signal Transduction
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Organ Regeneration
Response To Estradiol
Response To Glucagon
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fibroblast Proliferation
Cell Division
Ossification
Trophectodermal Cell Differentiation
Liver Development
Embryonic Placenta Development
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Viral Process
Megakaryocyte Differentiation
Lung Development
Enucleate Erythrocyte Differentiation
Positive Regulation By Host Of Viral Transcription
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Rhythmic Process
Embryonic Camera-type Eye Morphogenesis
Embryonic Skeletal System Development
Embryonic Process Involved In Female Pregnancy
Definitive Hemopoiesis
Pathways
Cellular Senescence
G2/M Transition
Orc1 removal from chromatin
Cyclin E associated events during G1/S transition
Cyclin A/B1 associated events during G2/M transition
G1/S Transition
G2 Phase
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
DNA Damage/Telomere Stress Induced Senescence
Synthesis of DNA
Regulation of DNA replication
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
APC/C:Cdc20 mediated degradation of mitotic proteins
Senescence-Associated Secretory Phenotype (SASP)
Regulation of APC/C activators between G1/S and early anaphase
S Phase
APC/C-mediated degradation of cell cycle proteins
Cell Cycle, Mitotic
Orc1 removal from chromatin
SCF(Skp2)-mediated degradation of p27/p21
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic G2-G2/M phases
Loss of Function of TGFBR2 in Cancer
PPARA activates gene expression
Metabolism of lipids and lipoproteins
Cellular Senescence
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Oncogene Induced Senescence
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Generic Transcription Pathway
TGFBR2 MSI Frameshift Mutants in Cancer
Fatty acid, triacylglycerol, and ketone body metabolism
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Activation of gene expression by SREBF (SREBP)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
50 interactors:
ARID4A
BRCA1
BRCA2
BTG1
CALM1
CDC20
CDC25C
CDC27
CDC6
CDK1
CDK2
CDK3
CDK7
CDKN1A
CDKN1B
CDT1
CKS1B
CKS1BP7
CKS2
DTNBP1
E2F1
E2F3
FEN1
FZR1
HERC5
HIRA
HIST1H1A
HIST1H1B
ITGB3BP
KAT2B
MYBL2
NFYA
PGR
POLA1
PRC1
PSMD4
PTMA
RAD23A
RB1
RBL1
RBL2
RPA1
SKP1
SKP2
SP1
TAF1
TP53
TRAF3IP1
UBTF
USP37
139 interactors:
AATF
AHR
AR
ARHGAP21
ARNT
ATF7IP
ATF7IP2
BCL11B
BCL6
BCOR
BRCA1
BTRC
C3orf17
CASP3
CASP6
CASP7
CBX5
CCNA1
CCNA2
CCND1
CD2
CDK1
CDK2
CEBPB
CSNK2A1
DDX5
DROSHA
E2F1
E2F2
E2F3
EGR1
ELF1
EP300
ESR1
ESR2
ESRRA
ESRRB
ESRRG
ETS1
GABPA
GATA1
GATA3
GATA4
HBZ
HCFC1
HDAC1
HDAC2
HIF1A
HINT1
HLTF
HMGA1
HNF4A
HOXC11
HSPA8
HTT
IL1B
JUN
KIF1A
KLF10
KLF4
KLF6
LDB1
LMO2
MAPK1
MAPK3
MAPK8
MEF2C
MEF2D
MIER1
MIS18BP1
MSX1
MYC
MYCN
MYOD1
MYOG
NAP1L1
NCOR1
NCOR2
NFKB1
NFKB2
NFYA
NFYB
NFYC
NKX3-1
NOS3
NR2F1
NR5A1
NUP62
OGT
PARP1
PER3
PML
POGZ
POU2F1
PPIG
PPP1R13L
PRKCZ
PRKDC
PSIP1
PSMC5
PURA
RARA
RB1
RBBP4
RBL1
REL
RELA
RNF4
RXRA
SENP6
SF3A1
SHC1
SKIV2L2
SMAD2
SMAD3
SMAD4
SMARCC1
SMARCC2
SOX10
SOX8
SP3
SP4
SREBF1
SREBF2
SRF
SUB1
SUMO1
TAF4
TAL1
TBP
TFAP2A
TLX3
TP53
TPI1
USP39
VHL
YY1
ZBTB16
ZBTB7A
Entrez ID
890
6667
HPRD ID
00453
01796
Ensembl ID
ENSG00000145386
ENSG00000185591
Uniprot IDs
P20248
E4Z9M7
G5E9M8
P08047
PDB IDs
1E9H
1FIN
1FVV
1GY3
1H1P
1H1Q
1H1R
1H1S
1H24
1H25
1H26
1H27
1H28
1JST
1JSU
1OGU
1OI9
1OIU
1OIY
1OKV
1OKW
1OL1
1OL2
1P5E
1PKD
1QMZ
1URC
1VYW
2BKZ
2BPM
2C4G
2C5N
2C5O
2C5V
2C5X
2C6T
2CCH
2CCI
2CJM
2I40
2IW6
2IW8
2IW9
2UUE
2UZB
2UZD
2UZE
2UZL
2V22
2WEV
2WFY
2WHB
2WIH
2WIP
2WMA
2WMB
2WPA
2WXV
2X1N
3EID
3EJ1
3EOC
3F5X
4BCK
4BCM
4BCN
4BCP
4EOI
4EOJ
4EOK
4EOL
4EOM
4EON
4EOO
4EOP
4EOQ
4EOR
4EOS
4FX3
1SP1
1SP2
1VA1
1VA2
1VA3
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Mitotic Cell Cycle
Cell Cycle Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Mitotic Cell Cycle Process
Regulation Of Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Organelle Organization
Cell Cycle Checkpoint
Cell Division
Regulation Of Cell Cycle Process
Positive Regulation Of Cellular Metabolic Process
Chromosome Organization
Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Chromatin Organization
Regulation Of Protein Metabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Mitotic Cell Cycle
Mitotic Nuclear Division
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Metabolic Process
Cellular Response To DNA Damage Stimulus
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Cellular Macromolecule Biosynthetic Process
Regulation Of Protein Catabolic Process
Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle Phase Transition
DNA Damage Checkpoint
Regulation Of Cell Proliferation
Regulation Of Cell Cycle Phase Transition
Mitotic Cell Cycle Checkpoint
Positive Regulation Of Gene Expression
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Signal Transduction By P53 Class Mediator
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Proteasomal Protein Catabolic Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Nitrogen Compound Metabolic Process
Chromatin Modification
DNA Replication
Positive Regulation Of Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Heterocycle Metabolic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Proliferation
Cellular Response To Organic Substance
Response To Organic Substance
Organ Development
Developmental Process
Multicellular Organismal Development
Anatomical Structure Development
Cellular Metabolic Process
System Development
Regulation Of Cellular Process
Regulation Of Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Response To Hormone
Response To Lipid
Tissue Development
Tagcloud
?
calm3
cblb
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
vav2
wilcoxon
yes
zfyve9
Tagcloud (Difference)
?
calm3
cblb
ccnd3
cdk6
cited1
dems
dok
elk3
fyn
git1
hck
lck
module
modules
nonmodule
p85beta
pdgfra
pib5pa
psd93
ptch2
sam68
sh3kbp1
shc
tgfbr1
tgfbr2
vav2
wilcoxon
yes
zfyve9
Tagcloud (Intersection)
?