EIF2S2 and PLEKHM1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF2S2	PLEKHM1
Gene Name		eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	pleckstrin homology domain containing, family M (with RUN domain) member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 2 Complex	Cytoplasm
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding Metal Ion Binding	Metal Ion Binding
	Biological Process	In Utero Embryonic Development Male Germ Cell Proliferation Translation Translational Initiation Male Gonad Development Gene Expression Cellular Protein Metabolic Process	Intracellular Signal Transduction
Pathways		Ribosomal scanning and start codon recognition Recycling of eIF2:GDP Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Breast cancer ( 22976474)	Parkinson's disease ( 20070850)
Protein-Protein Interactions		22 interactors: APLP1 APP CCDC90B CRMP1 CSNK2A1 CSNK2B EIF2B1 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF4G2 EIF5 HMGA1 KIAA1377 NCK1 PLEKHM1 PRKDC TLE1 TP53 UNC119 ZBTB16	8 interactors: BID EIF2S2 GADD45G MAPK6 MOB4 MUC2 PAFAH1B3 SERPINB9
Entrez ID		8894	9842
HPRD ID		04882	11439
Ensembl ID		ENSG00000125977	ENSG00000225190
Uniprot IDs		P20042 Q6IBR8	Q9Y4G2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translation In Response To Stress Regulation Of Translational Initiation Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Translation In Response To Stress Translational Initiation Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Nervous System Development Oligodendrocyte Development Central Nervous System Development Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Gene Expression Cell Development Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Metabolic Process Neurogenesis Negative Regulation Of Protein Metabolic Process Cellular Response To Stimulus Oligodendrocyte Differentiation Anatomical Structure Development Negative Regulation Of Gene Expression System Development Negative Regulation Of Translation Translation Regulation Of Catalytic Activity Anatomical Structure Morphogenesis Response To Stimulus Glial Cell Development Response To Abiotic Stimulus Cellular Response To Stress Response To Heat Multicellular Organismal Development Response To Glucose Positive Regulation Of Protein Metabolic Process Cell Differentiation Rhythmic Process Positive Regulation Of Cell Aging Cellular Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Response To Endoplasmic Reticulum Stress Macromolecule Biosynthetic Process B Cell Lineage Commitment
Tagcloud ?		biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34 unrecognized	ablated c1 cathepsin colocalizes ctx declined depleted disorganized dynein hydrolase lis1 lysosomal lysosome master microtubule microtubules nfat organization osteoclast osteoclasts pits polykaryons rankl resorption secretion shrna specialized unrecognized virtue
Tagcloud (Difference) ?		biosynthetic cd47 cycs dataset dj e2f6 encyclopedia extra fmr1 fxr2 gpr37 logical mapt nrf1 paelr park2 park6 park7 parkin pen2 perturbation pink1 psenen retrieved seq stringent tomm34	ablated c1 cathepsin colocalizes ctx declined depleted disorganized dynein hydrolase lis1 lysosomal lysosome master microtubule microtubules nfat organization osteoclast osteoclasts pits polykaryons rankl resorption secretion shrna specialized virtue
Tagcloud (Intersection) ?		unrecognized