ARHGEF7 and CD244

Number of citations of the paper that reports this interaction (PMID 16983070)
16

Data Source:
HPRD (in vivo)

		ARHGEF7	CD244
Gene Name		Rho guanine nucleotide exchange factor (GEF) 7	CD244 molecule, natural killer cell receptor 2B4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytosol Focal Adhesion Cell Cortex Lamellipodium Neuron Projection Neuronal Cell Body Protein Complex	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding	Receptor Activity Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Fibroblast Migration Lamellipodium Assembly Positive Regulation Of Rac GTPase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Lamellipodium Morphogenesis	Signal Transduction Blood Coagulation Leukocyte Migration
Pathways		EGFR downregulation Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Rho GTPase cycle Signaling by EGFR GPCR downstream signaling Ephrin signaling NRAGE signals death through JNK Signaling by Rho GTPases Signaling by EGFR in Cancer EPH-Ephrin signaling G alpha (12/13) signalling events	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Bilirubin levels ( 19414484) Menarche (age at onset) ( 21102462) Menopause (age at onset) ( 19448619)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		28 interactors: ADAM15 ARHGEF6 CALM1 CBLB CD244 CDC42 ERBB2IP GIT1 GIT2 LRRK2 MEOX2 NCK1 NCKIPSD PAK1 PAK2 PAK3 PPM1E PPM1F PXN RAC1 SCRIB SH2D1A SHANK1 SHANK2 TGFBR2 TUBB3 WAS YWHAG	5 interactors: ARHGEF7 CD247 CD48 LAT SH2D1B
Entrez ID		8874	51744
HPRD ID		05688	16121
Ensembl ID		ENSG00000102606	ENSG00000122223
Uniprot IDs		B7Z6G2 E9PDQ5 Q14155	Q9BZW8
PDB IDs		1BY1 1ZSG 2L3G
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Catalytic Activity Cell Morphogenesis Involved In Differentiation Regulation Of Protein Kinase Activity Regulation Of Signaling Cell Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Projection Organization Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Programmed Cell Death Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cell Adhesion Regulation Of T Cell Activation Neuron Projection Morphogenesis Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Organelle Organization Positive Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Cell Development Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Positive Regulation Of T Cell Activation Neuron Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Actin Cytoskeleton Organization Nervous System Development Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Positive Regulation Of Transferase Activity Axon Guidance Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Development	Immune System Process Regulation Of Cell Adhesion Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Lamellipodium Morphogenesis Fc Receptor Signaling Pathway Regulation Of Lamellipodium Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of T Cell Activation Regulation Of Immune System Process Defense Response Positive Regulation Of Fibroblast Migration Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Lamellipodium Organization Leukocyte Activation Positive Regulation Of Natural Killer Cell Mediated Immunity Response To Stimulus Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Defense Response To Virus By Virus Mast Cell Degranulation Regulation Of Body Fluid Levels Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Wound Healing Mast Cell Mediated Immunity Small GTPase Mediated Signal Transduction Focal Adhesion Assembly Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Fibroblast Migration Lysosome Localization Mast Cell Activation Cell Activation Response To Wounding Leukocyte Degranulation Lamellipodium Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Adherens Junction Assembly Lamellipodium Organization Negative Regulation Of ERBB Signaling Pathway
Tagcloud ?			accounting acpa aetiology apca apparently character citrullinated contradictory ctla4 deiminase drb1 genetics heritability histocompatibility hla incompletely interpreted mhc originated padi4 peptidylarginine ptpn22 ra rheumatoid stat4 subsets synovium update vital
Tagcloud (Difference) ?			accounting acpa aetiology apca apparently character citrullinated contradictory ctla4 deiminase drb1 genetics heritability histocompatibility hla incompletely interpreted mhc originated padi4 peptidylarginine ptpn22 ra rheumatoid stat4 subsets synovium update vital
Tagcloud (Intersection) ?