LDB1 and ISL1

Number of citations of the paper that reports this interaction (PMID 9452425)
36

Data Source:
HPRD (in vivo)

		LDB1	ISL1
Gene Name		LIM domain binding 1	ISL LIM homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Protein Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Enhancer Sequence-specific DNA Binding Chromatin Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding BHLH Transcription Factor Binding
	Biological Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of DNA-templated Transcription, Elongation Somatic Stem Cell Maintenance Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hemoglobin Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Mesenchymal Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Protein Homodimerization Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Macrophage Colony-stimulating Factor Production
Pathways			Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS			Dental caries ( 23259602)
Protein-Protein Interactions		26 interactors: ATXN1 CTDSP1 ESR1 IRAK3 ISL1 LHX2 LHX3 LHX6 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP	20 interactors: APP CDK6 CDKN2B ESR1 ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LHX4 LMO2 LMX1A NR2F1 PECR RELA RLIM SMAD3 SSBP4 ZNF511
Entrez ID		8861	3670
HPRD ID		09144	02650
Ensembl ID		ENSG00000198728	ENSG00000016082
Uniprot IDs		Q86U70	P61371
PDB IDs		2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Central Nervous System Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Central Nervous System Development Cellular Metabolic Process Brain Development Head Development Developmental Process Organ Development Anatomical Structure Development Forebrain Development Tube Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Pattern Specification Process Cell Differentiation Negative Regulation Of Signal Transduction Multicellular Organismal Development Neuron Differentiation Anatomical Structure Morphogenesis System Development Spinal Cord Motor Neuron Differentiation Generation Of Neurons Negative Regulation Of Signaling Transcription From RNA Polymerase II Promoter Neurogenesis	Organ Development Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process System Development Cell Differentiation Gene Expression Central Nervous System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Central Nervous System Neuron Differentiation Regulation Of Erythrocyte Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Forebrain Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Brain Development Biosynthetic Process Generation Of Neurons Head Development Cellular Nitrogen Compound Metabolic Process Ventral Spinal Cord Development Positive Regulation Of Metabolic Process Neurogenesis Cell Differentiation In Spinal Cord Nervous System Development Response To External Stimulus Axon Guidance Nitrogen Compound Metabolic Process
Tagcloud ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable
Tagcloud (Difference) ?		assemble bhlh compatible consensus e12 erythroid erythroleukemia erythropoiesis exist forced g1er hemopoietic immature lbd1 lim lmo2 maintain maturation mediate multiprotein normally oncoprotein others precursors presumed primarily proerythroblast scl whose	3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable
Tagcloud (Intersection) ?