NR1I2 and NUCB2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid)

		NR1I2	NUCB2
Gene Name		nuclear receptor subfamily 1, group I, member 2	nucleobindin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Extracellular Space Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding	DNA Binding Calcium Ion Binding Protein Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Signal Transduction Steroid Metabolic Process Gene Expression Intracellular Receptor Signaling Pathway Exogenous Drug Catabolic Process Xenobiotic Transport Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Drug Export
Pathways
Drugs		Vitamin E Erlotinib Estradiol Ethinyl Estradiol Rifampin Rifaximin Paclitaxel Hyperforin SR12813 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Rilpivirine
Diseases
GWAS			Height ( 20881960)
Protein-Protein Interactions		27 interactors: ACTN2 ATP6AP1 CHMP1A DYRK2 EIF3I FGR MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBR5	8 interactors: GADD45A GNAI3 GNAS NDN NR1I2 SMARCD1 STAR XPO1
Entrez ID		8856	4925
HPRD ID		04346	09726
Ensembl ID		ENSG00000144852	ENSG00000070081
Uniprot IDs		F1D8P9 O75469	E9PKG6 P80303
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Response To Hormone Regulation Of Metabolic Process Cell Communication Cellular Response To Hormone Stimulus Positive Regulation Of Metabolic Process Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Signal Transduction Response To Organic Substance Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Stimulus Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Stimulus Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Initiation RNA Metabolic Process Regulation Of Signal Transduction Cell Differentiation Regulation Of Cellular Process Response To Steroid Hormone Negative Regulation Of Cellular Metabolic Process Regulation Of Carbohydrate Metabolic Process Developmental Process Involved In Reproduction Regulation Of Signaling Gland Development Reproductive Structure Development Reproductive System Development In Utero Embryonic Development Mammary Gland Development Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated	Response To Drug Cellular Response To Catecholamine Stimulus Genetic Imprinting Cyclic Purine Nucleotide Metabolic Process Regulation Of Metabolic Process Cyclic Nucleotide Biosynthetic Process Cellular Response To Organic Substance Regulation Of Adenylate Cyclase Activity Signal Transduction Regulation Of Cyclase Activity Cellular Response To Organic Cyclic Compound Signaling Cyclic Nucleotide Metabolic Process Cellular Response To Lipid Cell Communication Drug Export Post-embryonic Body Morphogenesis Cellular Response To Luteinizing Hormone Stimulus Circadian Sleep/wake Cycle, REM Sleep Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Organic Substance Response To Luteinizing Hormone Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Cellular Response To Stimulus Response To Growth Factor Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Post-embryonic Development Ribosomal Small Subunit Export From Nucleus Insecticide Metabolic Process Response To Ionizing Radiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Response To Xenobiotic Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Purine Nucleotide Biosynthetic Process Regulation Of Gene Expression Ribose Phosphate Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Cell Surface Receptor Signaling Pathway Circadian Sleep/wake Cycle Process Fractalkine Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Platelet Activation Xenobiotic Transport Regulation Of Gene Expression, Epigenetic
Tagcloud ?		1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl	animal birth blot catch diets difference divided feeding gastric ghrelin groups growth immediately interact intrauterine iugr mucosa nesfatin newborn nutritional observation pregnancy produce rats retardation significance starting weaning whole
Tagcloud (Difference) ?		1h androstane benzo bms car carboxylate chlorophenyl cotreated cyp3a4 dihydropyridin hphs huh7 hydroxypropyl idazol imidazol morpholino noncanonical nonclassical noteworthy nr1i3 piperazine piperidin pregnane prototypical pxr pyrazol pyridin translocate yl	animal birth blot catch diets difference divided feeding gastric ghrelin groups growth immediately interact intrauterine iugr mucosa nesfatin newborn nutritional observation pregnancy produce rats retardation significance starting weaning whole
Tagcloud (Intersection) ?