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HDAC3 and NR2C1
Number of citations of the paper that reports this interaction (PMID
11463856
)
8
Data Source:
HPRD
(in vitro, in vivo)
HDAC3
NR2C1
Gene Name
histone deacetylase 3
nuclear receptor subfamily 2, group C, member 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Spindle Microtubule
Plasma Membrane
Transcriptional Repressor Complex
Nucleoplasm
PML Body
Molecular Function
Chromatin Binding
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Cyclin Binding
Chromatin DNA Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
NAD-dependent Histone Deacetylase Activity (H3-K9 Specific)
NAD-dependent Histone Deacetylase Activity (H4-K16 Specific)
NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Receptor Activity
Protein Binding
Zinc Ion Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Sequence-specific DNA Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Protein Phosphorylation
Chromatin Organization
Transcription, DNA-templated
Protein Deacetylation
Notch Signaling Pathway
Regulation Of Mitotic Cell Cycle
Circadian Rhythm
Negative Regulation Of Myotube Differentiation
Chromatin Modification
Regulation Of Protein Stability
Positive Regulation Of TOR Signaling
Circadian Regulation Of Gene Expression
Regulation Of Multicellular Organism Growth
Positive Regulation Of Transcription Factor Import Into Nucleus
Negative Regulation Of Apoptotic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of JNK Cascade
Neurotrophin TRK Receptor Signaling Pathway
Spindle Assembly
Histone H3-K9 Modification
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Fluid Shear Stress
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Gene Expression
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
PPARA activates gene expression
Organelle biogenesis and maintenance
Metabolism of lipids and lipoproteins
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
RORA activates circadian gene expression
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Signaling by NOTCH1
Transcriptional regulation of white adipocyte differentiation
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Signalling by NGF
Fatty acid, triacylglycerol, and ketone body metabolism
Chromatin organization
p75NTR negatively regulates cell cycle via SC1
HDACs deacetylate histones
Signaling by NOTCH
p75 NTR receptor-mediated signalling
REV-ERBA represses gene expression
Mitochondrial biogenesis
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional activation of mitochondrial biogenesis
Constitutive Signaling by NOTCH1 PEST Domain Mutants
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions
96 interactors:
ANKRD11
ANKRD12
AR
ARID4A
ATF3
BCL3
BCOR
BRINP1
BRMS1
CBFA2T3
CCND1
CCT5
CEBPD
CORO2A
CREB3
CREBBP
CSNK2A1
CTBP1
DAXX
DHX30
EED
EP300
EWSR1
GATA1
GATA2
GCM1
GPS2
GTF2I
GTF2IRD1
HDAC1
HDAC10
HDAC4
HDAC5
HDAC7
HDAC9
HIF1AN
HIST1H4A
HNF4A
HR
HSPA4
HSPA8
IL16
JUN
KLF6
LCOR
MAPK11
MAPK14
MBD1
NACC1
NCOR1
NCOR2
NFKBIA
NR0B2
NR2C1
NR2E3
NRIP1
PARP1
PHB2
PIAS2
PML
PPARD
PPARG
PPP4C
PPP4R1
PRKDC
RARA
RB1
RBBP4
RELA
RUNX1
RUNX1T1
RUNX2
RXRA
SMYD1
SRC
SREBF2
SRY
STAT3
SUV39H1
SYK
TAB2
TBL1X
TBL1XR1
THAP11
THAP7
THRA
THRB
TMPO
TNFRSF14
TP53
TXNIP
VHL
WISP2
XPO1
YY1
ZBTB16
8 interactors:
AR
ESR1
HDAC3
HDAC4
NR2C2
NRIP1
NUDT3
UBC
Entrez ID
8841
7181
HPRD ID
08950
03318
Ensembl ID
ENSG00000171720
ENSG00000120798
Uniprot IDs
O15379
H9NIM2
H9NIM3
P13056
PDB IDs
4A69
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Gene Expression
RNA Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Cellular Process
Cellular Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Response To Organic Substance
Organ Development
Chromatin Organization
Cellular Response To Organic Substance
Cell Differentiation
Hemopoiesis
DNA-templated Transcription, Initiation
Chromosome Organization
Developmental Process
Immune System Development
Cellular Response To Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Intracellular Receptor Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
DNA-templated Transcription, Initiation
Transcription, DNA-templated
RNA Biosynthetic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Rhythmic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Steroid Hormone Mediated Signaling Pathway
Cellular Nitrogen Compound Metabolic Process
RNA Metabolic Process
Hormone-mediated Signaling Pathway
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Gene Expression
Signaling
Cell Communication
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Cellular Response To Steroid Hormone Stimulus
Circadian Rhythm
Negative Regulation Of Gene Expression
Histone H4 Deacetylation
Negative Regulation Of Biosynthetic Process
Response To Organic Substance
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Histone H3 Deacetylation
Androgen Receptor Signaling Pathway
Histone H3-K9 Modification
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Sex Differentiation
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Organic Substance
Tagcloud
?
acetylation
acetyltransferases
atf2
chip
d54mg
deacetylase
erythematosus
favoring
gcn5
globally
h4
h4ac
h4k12
h4k16
h4k5
h4k8
hdac11
imbalance
irf1
k12
k16
k8
look
lupus
monocytes
overexpressing
pcaf
seq
sle
Tagcloud (Difference)
?
acetylation
acetyltransferases
atf2
chip
d54mg
deacetylase
erythematosus
favoring
gcn5
globally
h4
h4ac
h4k12
h4k16
h4k5
h4k8
hdac11
imbalance
irf1
k12
k16
k8
look
lupus
monocytes
overexpressing
pcaf
seq
sle
Tagcloud (Intersection)
?