SNX3 and VPS35

Number of citations of the paper that reports this interaction (PMID 22673115)
12

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SNX3	VPS35
Gene Name		sorting nexin 3	vacuolar protein sorting 35 homolog (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Endosome Membrane Extrinsic Component Of Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Retromer Complex Extracellular Vesicular Exosome Tubular Endosome
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Protein Transporter Activity
	Biological Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Vesicle Organization Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Protein Transport Transferrin Transport Negative Regulation Of Protein Catabolic Process Hemoglobin Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport	Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Transcytosis Negative Regulation Of Late Endosome To Lysosome Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking	WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 SCNN1A STX11 USP10 VPS35	9 interactors: APP FAM21C MTNR1B SNX1 SNX3 VEGFA VPS26B VPS29 ZNF512B
Entrez ID		8724	55737
HPRD ID		09333	06085
Ensembl ID		ENSG00000112335
Uniprot IDs		O60493	Q96QK1
PDB IDs		2YPS	2R17
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Protein K6-linked Ubiquitination Signal Transduction In Response To DNA Damage Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H3-K4 Methylation DNA Metabolic Process Response To Ionizing Radiation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Histone Methylation DNA Recombination Cellular Response To Stress Regulation Of Histone Acetylation Regulation Of Histone Methylation Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Histone H4-K16 Acetylation Response To Stress Response To Radiation Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Intracellular Transport Regulation Of Histone Modification Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Leukocyte Activation Involved In Immune Response Protein Polyubiquitination Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Lagging Strand Elongation Pro-B Cell Differentiation Negative Regulation Of Protein Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Neutrophil Degranulation Cytotoxic T Cell Degranulation Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Establishment Of Integrated Proviral Latency Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation	Retrograde Transport, Endosome To Golgi Vesicle-mediated Transport Endosomal Transport Establishment Of Localization In Cell Cellular Localization Intracellular Transport Retrograde Transport, Endosome To Plasma Membrane Regulation Of Cell Development Platelet Degranulation Positive Regulation Of Protein Kinase D Signaling Basophil Chemotaxis Intralumenal Vesicle Formation Transport Positive Regulation Of Protein Localization To Early Endosome Synaptic Growth At Neuromuscular Junction Negative Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Vein Morphogenesis Primitive Erythrocyte Differentiation VEGF-activated Neuropilin Signaling Pathway Regulation Of Receptor Activity Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Barbed-end Actin Filament Capping Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Deacetylase Activity Protein Transport Cell Maturation Establishment Of Protein Localization Positive Regulation Of Lymphangiogenesis Cardiac Vascular Smooth Muscle Cell Development Positive Regulation Of Mast Cell Chemotaxis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Lamellipodium Morphogenesis Collateral Sprouting Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Axon Midline Choice Point Recognition Regulation Of Histone Deacetylase Activity Regulation Of Neurogenesis Regulation Of Endocytosis Positive Regulation Of Deacetylase Activity Coronary Artery Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Platelet Activation Regulation Of Cell-substrate Adhesion
Tagcloud ?		altogether biogenesis degradative depends detachment endocytic endocytosis endosomal endosomes find homology intralumenal knockdown lysosomes maturation multivesicular nexin phosphoinositides prevents px recycling redundant restores retrograde shares snx12 sorting turn vesicles	allosteric biophysical cargo consists deciphered disrupts endosomal endosomes fret golgi gtpase hela insights instrumental nexins perturbed rab7 recognizing recruit recruitment recruits recycle retromer snx sorting sub vacuolar vps26
Tagcloud (Difference) ?		altogether biogenesis degradative depends detachment endocytic endocytosis find homology intralumenal knockdown lysosomes maturation multivesicular nexin phosphoinositides prevents px recycling redundant restores retrograde shares snx12 turn vesicles	allosteric biophysical cargo consists deciphered disrupts fret golgi gtpase hela insights instrumental nexins perturbed rab7 recognizing recruit recruitment recruits recycle retromer snx sub vacuolar vps26
Tagcloud (Intersection) ?		endosomal endosomes sorting