PDLIM4 and TRIP6

Number of citations of the paper that reports this interaction (PMID 10826496)
13

Data Source:
HPRD (in vitro, two hybrid)

		PDLIM4	TRIP6
Gene Name		PDZ and LIM domain 4	thyroid hormone receptor interactor 6
Image
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex
	Molecular Function	Protein Binding Zinc Ion Binding	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding
	Biological Process		Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)	Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)
Protein-Protein Interactions		5 interactors: ABCA1 PTPN13 RBPMS TRIP6 ZNF408	105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1
Entrez ID		8572	7205
HPRD ID		04571	04242
Ensembl ID		ENSG00000131435	ENSG00000087077
Uniprot IDs		P50479	F2ZC06 Q15654
PDB IDs		2EEG 2V1W	1X61 2DLO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Interleukin-1 Beta Secretion Regulation Of Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Intracellular Transport Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Regulation Of Intracellular Protein Transport Regulation Of Signaling Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Positive Regulation Of Protein Transport Platelet Dense Granule Organization Cellular Macromolecule Biosynthetic Process Phospholipid Efflux Phagocytosis, Engulfment Macromolecule Biosynthetic Process Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of Intracellular Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Cholesterol Response To Laminar Fluid Shear Stress Regulation Of SMAD Protein Import Into Nucleus Membrane Invagination Reverse Cholesterol Transport Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Positive Regulation Of Cholesterol Transport Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Cholesterol Efflux Response To Cholesterol Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Regulation Of Protein Transport	Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process
Tagcloud ?		adjacent benign c21orf63 distinguish done fabp5 flj14084 gstp1 hypermethylation implicating kiaa1210 methylation microarrays mlp panel prima1 profiling prostate ptgs2 quantitative sensitivities sorbs1 sox4 specificities svil taqman tissues tu3a u133	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Difference) ?		adjacent benign c21orf63 distinguish done fabp5 flj14084 gstp1 hypermethylation implicating kiaa1210 methylation microarrays mlp panel prima1 profiling prostate ptgs2 quantitative sensitivities sorbs1 sox4 specificities svil taqman tissues tu3a u133	adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression
Tagcloud (Intersection) ?