SCIN and ACTG1

Number of citations of the paper that reports this interaction (PMID 1331119)
4

Data Source:
HPRD (in vitro)

		SCIN	ACTG1
Gene Name		scinderin	actin gamma 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Cell Cortex Protein Complex Extracellular Vesicular Exosome	Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Membrane Myofibril Filamentous Actin Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Phosphatidylserine Binding Actin Binding Calcium Ion Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Cell Proliferation Calcium Ion-dependent Exocytosis Regulation Of Chondrocyte Differentiation Positive Regulation Of Apoptotic Process Actin Nucleation Positive Regulation Of Megakaryocyte Differentiation Actin Filament Severing Positive Regulation Of Secretion Actin Filament Capping	Retina Homeostasis Movement Of Cell Or Subcellular Component Axon Guidance Cell Junction Assembly Adherens Junction Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Sarcomere Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Membrane Organization Platelet Aggregation
Pathways			Axon guidance Gap junction degradation Adherens junctions interactions Translocation of GLUT4 to the plasma membrane L1CAM interactions Recycling pathway of L1 VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling Interaction between L1 and Ankyrins Cell-cell junction organization EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Cell junction organization Formation of annular gap junctions Gap junction trafficking Signaling by VEGF Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ACTA1 ACTC1 ACTG1	60 interactors: ABLIM1 ACTB ANXA5 APOE ATF7IP BCAP31 BRCA1 CAP1 CAP2 CAPZA3 CCDC22 CDKN2A CFL1 CFL2 COTL1 CTBP2 CTTN CYBB DISC1 DNASE1 DSTN DYNLL1 EHHADH EIF6 FHOD1 FPR1 GIT2 GSN GZMA GZMK LGALS13 LIG4 LSP1 MAP1A MAPK6 MYO1A MYOC NDRG1 NR3C2 PFN2 PLD1 PLEC PPP1R9A PRSS23 PSEN2 PTPRO RPS6KA5 SCIN SH3GL2 ST3GAL3 SUMO4 TMSB4X TMSB4Y TNIK VASP VIL1 WASF1 WASL WDYHV1 WIPF1
Entrez ID		85477	71
HPRD ID		11539	00017
Ensembl ID		ENSG00000006747	ENSG00000184009
Uniprot IDs		Q9Y6U3	P63261
PDB IDs		3FG6
Enriched GO Terms of Interacting Partners?		Myofibril Assembly Actomyosin Structure Organization Skeletal Muscle Thin Filament Assembly Striated Muscle Cell Development Skeletal Myofibril Assembly Muscle Cell Development Striated Muscle Cell Differentiation Muscle Cell Differentiation Muscle Filament Sliding Actin-myosin Filament Sliding Organelle Assembly Actin-mediated Cell Contraction Muscle Structure Development Actin Cytoskeleton Organization Actin Filament-based Movement Actin Filament-based Process Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Skeletal Muscle Fiber Adaptation Muscle Contraction Movement Of Cell Or Subcellular Component Muscle System Process Muscle Organ Development Cell Development Actin Filament Organization Striated Muscle Tissue Development Cellular Component Assembly Muscle Tissue Development Anatomical Structure Morphogenesis Skeletal Muscle Adaptation Organelle Organization Cardiac Myofibril Assembly Skeletal Muscle Fiber Development Cell Differentiation Myotube Cell Development Response To Lithium Ion Platelet Aggregation System Development Muscle Fiber Development Sarcomere Organization Cardiac Muscle Contraction Cardiac Muscle Tissue Morphogenesis Myotube Differentiation Retina Homeostasis Muscle Tissue Morphogenesis Multicellular Organismal Development Heart Contraction Cardiac Muscle Cell Development Muscle Organ Morphogenesis Anatomical Structure Development	Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Actin Polymerization Or Depolymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Organelle Organization Organelle Organization Regulation Of Cellular Component Size Chemotaxis Cell Projection Organization Neurogenesis Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Complex Assembly Neuron Projection Development Negative Regulation Of Protein Polymerization Movement Of Cell Or Subcellular Component Axon Guidance Generation Of Neurons Actin Filament Severing Positive Regulation Of Cellular Component Biogenesis Locomotion Regulation Of Protein Depolymerization Cell Development Response To External Stimulus Neuron Development Nervous System Development Axon Development Regulation Of Protein Complex Disassembly Regulation Of Cell Projection Organization Actin Filament Depolymerization Neuron Projection Morphogenesis Axonogenesis Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Signal Transduction
Tagcloud ?		a549 actin advantage arrest b1 capping carcinoma colony cytometry depletion excess g0 g1 h1299 homologue interference knockdown lentivirus lung p21 parp rnai scinderin severing silencing sub took yet zebrafish	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?		a549 actin advantage arrest b1 capping carcinoma colony cytometry depletion excess g0 g1 h1299 homologue interference knockdown lentivirus lung p21 parp rnai scinderin severing silencing sub took yet zebrafish	alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdhb pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?