IKBKG and RPS6KB2

Number of citations of the paper that reports this interaction (PMID 20098747)
10

Data Source:
BioGRID (pull down)

		IKBKG	RPS6KB2
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	ribosomal protein S6 kinase, 70kDa, polypeptide 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Intracellular Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Mitotic Spindle	Nucleoplasm Cytoplasm
	Molecular Function	Signal Transducer Activity Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Binding Linear Polyubiquitin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity ATP Binding Peptide Binding
	Biological Process	Activation Of MAPK Activity B Cell Homeostasis Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Apoptotic Process Inflammatory Response Immune Response Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Response To Virus Viral Process Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Establishment Of Vesicle Localization Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Neuron Death Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Translation Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Kinase B Signaling Innate Immune Response Positive Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling
Pathways		Signaling by the B Cell Receptor (BCR) Downstream TCR signaling Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade IRAK1 recruits IKK complex Downstream signaling events of B Cell Receptor (BCR) Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade IRAK1 recruits IKK complex JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System activated TAK1 mediates p38 MAPK activation TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade IKK complex recruitment mediated by RIP1 Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		225 interactors: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 ASAP1 AVPI1 BCL10 BIRC2 BIRC3 C19orf12 C19orf57 CALB1 CALCOCO2 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGLN3 EIF1AX EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GRK4 GSK3B GTF2E1 GUCY1A3 GYG2 H1F0 HBZ HCLS1 HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 HTT ID1 ID3 IKBKB INO80E IRAK1 ITK JAK2 JAK3 KANSL2 KIAA1598 KIR3DX1 KRT18 KRT8 LCK LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MAFIP MALT1 MAP3K14 MAP3K2 MAPRE1 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 PA2G4 PARK2 PARP10 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMAL1 POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PSMA3 RAB11A RAB11B RAB11FIP3 RALBP1 RBBP8 RBCK1 RBM34 RBM8A RBP1 RELA RET RHOA RIPK1 RIPK2 RNF11 RNF31 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPT9 SGK1 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF2 TRAF3IP2 TRAF6 TRIM29 TRIM31 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBB UBC UBE2D3 USP10 USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZZZ3	20 interactors: ATP5A1 BRAF BTK COASY CSNK2B EEF2K EP300 FBXO25 IKBKG KAT2B LYN MAPK8IP2 MTOR NEDD4L PDPK1 PRKCE RPS6 SRC SRPK1 SYK
Entrez ID		8517	6199
HPRD ID		02217	10203
Ensembl ID		ENSG00000073009	ENSG00000175634
Uniprot IDs		C9J1R1 Q9Y6K9	Q9UBS0
PDB IDs		2JVX 2JVY 3BRT 3BRV 3CL3 3FX0
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Signal Transduction Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Innate Immune Response Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Innate Immune Response Regulation Of Apoptotic Process Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Cell Death Positive Regulation Of Immune System Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Regulation Of Cytokine Production Immune System Process Negative Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Stimulus Defense Response Regulation Of Nitrogen Compound Metabolic Process Immune Response Programmed Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Type I Interferon Production	Regulation Of Protein Phosphorylation Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Phosphate-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Kinase Activity Viral Process Regulation Of Phosphorus Metabolic Process Innate Immune Response Protein Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Organic Substance Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Response To Hormone Immune Response Protein Phosphorylation Response To Peptide Hormone Defense Response Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Insulin Response To Peptide Cellular Protein Metabolic Process Cellular Response To Organic Substance Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Signaling Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Cellular Response To Insulin Stimulus Cell Communication Positive Regulation Of Protein Modification Process Immune System Process Fc-epsilon Receptor Signaling Pathway Peptidyl-amino Acid Modification Peptidyl-tyrosine Autophosphorylation Cell Activation Cellular Metabolic Process
Tagcloud ?		122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf	administrated arylnaphthalide atg12 atg5 autophagic bafilomycin beclin bnip3 chloroquine inc ja justicia justicidin lc3 lignan methyladenine mrfp p62 p70s6k pdk1 periodicals physiol procumbens ptflc3 puncta shrna sqstm1 vad wiley
Tagcloud (Difference) ?		122c 2012cb944901 9qh azoospermia blimp1 dazl ddx4 declare dppa3 envisioned fam122c funds grants hef ipsc ipscs lin28 poi poi1 poi2 prdm1 q26 rbmx stella sublines talents vasa xq znf	administrated arylnaphthalide atg12 atg5 autophagic bafilomycin beclin bnip3 chloroquine inc ja justicia justicidin lc3 lignan methyladenine mrfp p62 p70s6k pdk1 periodicals physiol procumbens ptflc3 puncta shrna sqstm1 vad wiley
Tagcloud (Intersection) ?