IRS4 and SOCS6

Number of citations of the paper that reports this interaction (PMID 12052866)
26

Data Source:
HPRD (in vitro)

		IRS4	SOCS6
Gene Name		insulin receptor substrate 4	suppressor of cytokine signaling 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane	Immunological Synapse Cytoplasm
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process	Negative Regulation Of Protein Kinase Activity Defense Response JAK-STAT Cascade Proteasomal Protein Catabolic Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of JAK-STAT Cascade Negative Regulation Of T Cell Activation
Pathways		IRS-related events triggered by IGF1R Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IGF1R signaling cascade	Signaling by SCF-KIT Regulation of KIT signaling
Drugs
Diseases
GWAS			Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		17 interactors: CRK CRKL EGFR ERBB2 GRB2 IGF1R MTNR1A MTNR1B NISCH PIK3CA PIK3R1 PRKCZ PTPN11 PTPN6 SOCS6 SOCS7 YWHAG	22 interactors: ACVR1 BMPR1B EFEMP1 INSR IRS2 IRS4 KDM1A KIT PIK3R1 PIK3R2 RBCK1 RELA SMURF2 TCEB1 TCEB2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		8471	9306
HPRD ID		04620	05491
Ensembl ID		ENSG00000133124	ENSG00000170677
Uniprot IDs		O14654	O14544
PDB IDs			2VIF
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide Cellular Response To Insulin Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Cellular Response To Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Insulin Response To Peptide Hormone Regulation Of Phosphorylation Response To Peptide Regulation Of Protein Kinase Activity Response To Organonitrogen Compound Response To Hormone Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Signaling Regulation Of T Cell Activation Signal Transduction Response To Organic Substance Signaling Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Response To Growth Factor Regulation Of Lymphocyte Activation Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cell Activation Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process T Cell Costimulation Regulation Of Immune Response	Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Growth Factor Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Cellular Response To Organic Substance Response To Insulin Response To Stimulus Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Peptide Viral Process ERBB Signaling Pathway Cellular Protein Modification Process Cellular Response To Stimulus Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Hormone Response To Stress Defense Response Regulation Of Cartilage Development Negative Regulation Of Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Tagcloud ?		arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b wipf2	6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2
Tagcloud (Difference) ?		arg35 arhg5 cbl cblb del digested downscaled doxycycline dyn2 errfi flp hek293 hsp71 hsp7c input l747 optimisation pc9 ptpra purifications quantities retroviral s752 sos1 sos2 tagged tap usb3b wipf2	6r c3 castration cis constitutively crpc erk1 exogenous express gp130 il jak1 jak2 jak3 lncap ned neuroendocrine s17 secretes sh2 slightly socs1 socs7 stat3 subline sublines suppressors though tyk2
Tagcloud (Intersection) ?