TRIM63 and USP8

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		TRIM63	USP8
Gene Name		tripartite motif containing 63, E3 ubiquitin protein ligase	ubiquitin specific peptidase 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Acrosomal Vesicle Nucleoplasm Cytoplasm Early Endosome Golgi Apparatus Cytosol Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding
	Biological Process	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus	Mitotic Cytokinesis Endosome Organization Ras Protein Signal Transduction Cell Proliferation Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1	30 interactors: BIRC6 CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 GRAP2 GRB2 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SLBP SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ
Entrez ID		84676	9101
HPRD ID		05843	04405
Ensembl ID		ENSG00000158022	ENSG00000138592
Uniprot IDs		B4DN95 Q969Q1	P40818
PDB IDs		2D8U 3DDT	1WHB 2A9U 2GFO 2GWF 3N3K
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination	Cell Separation After Cytokinesis Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Mitotic Metaphase Plate Congression Metaphase Plate Congression Regulation Of Mitotic Spindle Organization Establishment Of Chromosome Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Cell Cycle Process Regulation Of Centrosome Duplication Cell Cycle Mitotic Nuclear Division Regulation Of Centrosome Cycle Mitotic Cell Cycle Process Endosomal Transport Regulation Of Organelle Organization Nucleus Organization Mitotic Cell Cycle Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Cell Division Membrane Organization Regulation Of Microtubule-based Process Regulation Of Cell Cycle Process Intracellular Transport Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Chromosome Segregation Negative Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Nuclear Division Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Establishment Of Localization In Cell Regulation Of Cytoskeleton Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Organelle Localization Regulation Of ERBB Signaling Pathway Virion Assembly Viral Life Cycle Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Regulation Of Cellular Process Cellular Protein Catabolic Process Protein Transport
Tagcloud ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Difference) ?		benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels	ampa ampar ampars antagonizes dephosphorylation deubiquitinating deubiquitination downscaling dub e3 forces homeostatic internalization inversely ligase lysosomes mechanistic nedd4 nmdar opposing plasticity redistributed scaling spines strength strikingly synapses synaptic ubiquitination
Tagcloud (Intersection) ?