AKT1S1 and RPTOR

Number of citations of the paper that reports this interaction (PMID 19446321)
187

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology)

		AKT1S1	RPTOR
Gene Name		AKT1 substrate 1 (proline-rich)	regulatory associated protein of MTOR, complex 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol TORC1 Complex	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Dendrite TORC1 Complex Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	RNA Polymerase III Type 1 Promoter DNA Binding RNA Polymerase III Type 2 Promoter DNA Binding RNA Polymerase III Type 3 Promoter DNA Binding TFIIIC-class Transcription Factor Binding Protein Binding Protein Kinase Binding Protein Complex Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Size Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Cellular Response To Heat	Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Insulin Receptor Signaling Pathway Regulation Of Cell Size Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Cellular Response To Heat Positive Regulation Of Transcription From RNA Polymerase III Promoter Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling AKT phosphorylates targets in the cytosol Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) HSF1-dependent transactivation PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer Cellular response to heat stress NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R HSF1-dependent transactivation Release of eIF4E Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Release of eIF4E Cellular response to heat stress S6K1-mediated signalling mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS			Obesity ( 23563607)
Protein-Protein Interactions		12 interactors: AKT1 AKT2 EIF6 MAPKAP1 MLST8 MTOR RICTOR RPS6KA5 RPTOR TCEA2 YWHAG YWHAQ	20 interactors: AKT1S1 EIF4EBP1 ICK IRS1 IRS2 MAPK1 MAPK3 MARK4 MLST8 MTOR PLD2 PRKAA1 PRKAA2 PRR5L RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB
Entrez ID		84335	57521
HPRD ID		12441	06184
Ensembl ID		ENSG00000204673	ENSG00000141564
Uniprot IDs		Q96B36	F5H7J5 Q6DKI0 Q8N122
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Costimulation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Response To Insulin Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Phosphatidylinositol-mediated Signaling Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Phosphorylation Response To Peptide Hormone Positive Regulation Of T Cell Activation Cellular Response To Organonitrogen Compound Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Phosphorylation Response To Peptide Regulation Of Fatty Acid Beta-oxidation Fc-epsilon Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Regulation Of Endothelial Cell Proliferation Positive Regulation Of Protein Modification Process Positive Regulation Of Cell-cell Adhesion Regulation Of Phosphorus Metabolic Process Regulation Of Rac GTPase Activity TOR Signaling Fc Receptor Signaling Pathway Positive Regulation Of TOR Signaling Cellular Response To Hormone Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of T Cell Activation Positive Regulation Of Cell Activation Response To Heat	Cellular Response To Organonitrogen Compound Insulin Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Insulin Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Peptide Hormone Enzyme Linked Receptor Protein Signaling Pathway Regulation Of TOR Signaling Response To Peptide Neurotrophin Signaling Pathway Cellular Response To Hormone Stimulus Intracellular Signal Transduction Cell Communication Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Response To Heat Response To Hormone Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Signal Transduction Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Heat Fc-epsilon Receptor Signaling Pathway Response To Stimulus TOR Signaling Signaling Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Cellular Response To Heat Positive Regulation Of TOR Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed	ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Difference) ?		advancement applicable automated avoidance believe broadly ccnd1 incorporate intact lethal lysis multiplex overtreatment perturbed phosphoserines phosphothreonine platforms ppras40 prognostication ps6 quantify quantitatively reproducibly rps6 smad4 spp1 substitute suited witnessed	ablation balanced cns complexes contributions delicately functionally hypomyelination integrates lipogenesis lipogenic minor mtor mtorc1 mtorc2 myelin myelination oligodendrocyte oligodendrocytes overactivation overtones practical rapamycin reliant rictor sclerosis tsc1 tuberous
Tagcloud (Intersection) ?