NR0B2 and HNF4A

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid)

		NR0B2	HNF4A
Gene Name		nuclear receptor subfamily 0, group B, member 2	hepatocyte nuclear factor 4, alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Complex Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cholesterol Metabolic Process Response To Glucose Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Organ Regeneration Positive Regulation Of Insulin Secretion Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Ornithine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Proliferation Response To Glucose Gene Expression Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Glucose Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis SMAD Protein Signal Transduction Regulation Of Growth Hormone Receptor Signaling Pathway Triglyceride Homeostasis Positive Regulation Of Cholesterol Homeostasis
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			C-reactive protein ( 21300955 22939635) Cholesterol, total ( 20686565) HDL cholesterol ( 19060906 20686565) Type 2 diabetes ( 21874001 22158537) Ulcerative colitis ( 19915572 23128233)
Protein-Protein Interactions		46 interactors: AR CHRD DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 IL3RA NCOA3 NR1H2 NR1H3 NR1I3 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 UBC VDR XBP1 ZAP70 ZMYND10	62 interactors: ANP32B COPS5 CREBBP ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HNF1A MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 SUMO1 SUMO2 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3
Entrez ID		8431	3172
HPRD ID		05219	02612
Ensembl ID		ENSG00000131910	ENSG00000101076
Uniprot IDs		Q15466	F1D8S2 F1D8T0 F1D8T1 P41235
PDB IDs		1YUC 2Q3Y 2Z4J 4DOR	1PZL 3CBB 3FS1 4B7W 4IQR
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lipid Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound Cellular Response To Hormone Stimulus RNA Metabolic Process Response To Steroid Hormone Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Lipid Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hormone Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Response To Organic Cyclic Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process	Transcription, DNA-templated RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Metabolic Process Response To Hormone Stem Cell Maintenance Cellular Response To Organic Substance
Tagcloud ?		abolished adenovirus ag490 amp ataxia atm carboxykinase gh gluconeogenesis hepatic hepatocytes heterodimer interacted ku mediating metformin null orphan partner pepck phosphatidylinositol phosphoenolpyruvate physically pivotal regulating shp stat5 superfamily telangiectasia	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts
Tagcloud (Difference) ?		abolished adenovirus ag490 amp ataxia atm carboxykinase gh gluconeogenesis hepatic hepatocytes heterodimer interacted ku mediating metformin null orphan partner pepck phosphatidylinositol phosphoenolpyruvate physically pivotal regulating shp stat5 superfamily telangiectasia	bmi1 catalyze cdx2 differentiating ectoderm eed endoderm h2ak119ub1 h3k9me3 hes house kind1 lineage lineages map2 mef2c mesoderm modifiers necessitates pcg polycomb prcs qrt ring1b sox1 specification suz12 tbx5 transcripts
Tagcloud (Intersection) ?