CASP10 and RIOK3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CASP10	RIOK3
Gene Name		caspase 10, apoptosis-related cysteine peptidase	RIO kinase 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Apoptotic Signaling Pathway	Protein Phosphorylation Chromosome Segregation
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAIL signaling Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		30 interactors: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP	7 interactors: BCL2L11 CASP10 CDC42 CREB3L3 FBXO25 PAK2 UBC
Entrez ID		843	8780
HPRD ID		03458	04659
Ensembl ID		ENSG00000003400	ENSG00000101782
Uniprot IDs		Q92851	B0YJ89 B4E1Q4 O14730
PDB IDs
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Execution Phase Of Apoptosis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Protein Processing Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Endopeptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Glial Cell Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Macrophage Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Communication Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Neuron Apoptotic Process Intracellular Signal Transduction Proteolysis Regulation Of Necroptotic Process Positive Regulation Of Neuron Apoptotic Process Neuron Death Regulation Of Cellular Protein Metabolic Process Hepatocyte Apoptotic Process Signaling Positive Regulation Of Neuron Death	Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Death Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Positive Regulation Of Cell Cycle Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stress Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Apoptotic Process Apoptotic Signaling Pathway Programmed Cell Death Immune System Process Cell Death Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Neuron Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of Protein Metabolic Process Regulation Of ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response Positive Regulation Of Kinase Activity Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Viral Process Positive Regulation Of Transferase Activity T Cell Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Immune Response Regulation Of Signaling Signal Transduction Antigen Receptor-mediated Signaling Pathway Regulation Of Proteolysis Submandibular Salivary Gland Formation Actin Filament Branching Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Tagcloud ?		arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn	adaptive adaptor adds antiviral blocks bridges bridging combat complexity cytosolic defense elicits gammaherpesvirus herpesvirus ifns innate interacts interferon interferons irf3 kinome limiting nucleic physically screens shaping stranded tbk1 transcriptome
Tagcloud (Difference) ?		arginine bcl3 dap1 derepression epigenetic epigenetically governs hdac1 hodgkin hoxa5 hrk indirectly lymphoma master methyltransferase offer p52 polycomb prc2 prmt5 rb1 rbl2 reactivation repression repressor retinoblastoma tp53k372 trigger turn	adaptive adaptor adds antiviral blocks bridges bridging combat complexity cytosolic defense elicits gammaherpesvirus herpesvirus ifns innate interacts interferon interferons irf3 kinome limiting nucleic physically screens shaping stranded tbk1 transcriptome
Tagcloud (Intersection) ?