CASP9 and SRF

Number of citations of the paper that reports this interaction (PMID 11387340)
8

Data Source:
HPRD (in vitro)

		CASP9	SRF
Gene Name		caspase 9, apoptosis-related cysteine peptidase	serum response factor (c-fos serum response element-binding transcription factor)
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Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Apoptosome	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Aging Fibroblast Growth Factor Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Fc-epsilon Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Response To Antibiotic Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Dexamethasone Stimulus Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Response To DNA Damage Stimulus	Patterning Of Blood Vessels Response To Hypoxia Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Transcription From RNA Polymerase II Promoter Cell-matrix Adhesion Heart Development Long-term Memory Negative Regulation Of Cell Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Positive Regulation Of Transcription Via Serum Response Element Binding Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Neuron Projection Development Regulation Of Water Loss Via Skin Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis MRNA Transcription From RNA Polymerase II Promoter Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Developmental Growth Neuron Development Erythrocyte Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Long Term Synaptic Depression Heart Trabecula Formation Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Negative Regulation Of Beta-amyloid Clearance
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes Cytochrome c-mediated apoptotic response SMAC-mediated apoptotic response Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Role of DCC in regulating apoptosis Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) Activation of caspases through apoptosome-mediated cleavage Formation of apoptosome PI3K/AKT activation PI-3K cascade Apoptotic factor-mediated response NOD1/2 Signaling Pathway PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Extrinsic Pathway Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		44 interactors: ABL1 AKT1 APAF1 BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP	72 interactors: ALDH3A1 ASCC1 ASCC2 ASCC3 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CNTN2 CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MKL1 MKL2 MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARG REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 UBE2I ZIC3
Entrez ID		842	6722
HPRD ID		03756	02788
Ensembl ID		ENSG00000132906	ENSG00000112658
Uniprot IDs		F8VVS7 P55211	F5H6V4 P11831
PDB IDs		1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS	1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Peptidase Activity Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Protein Processing Regulation Of Signal Transduction Regulation Of Signaling Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Negative Regulation Of Cell Death	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Organ Development Cell Differentiation Developmental Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Tissue Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Response To Lipid Anatomical Structure Development Regulation Of Cellular Process Anatomical Structure Morphogenesis System Development Response To Hormone Cellular Response To Organic Substance Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Heart Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Response To Steroid Hormone Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process
Tagcloud ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Difference) ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp4 casp8 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	ali bellan biol chem classes coactivator coexpression concluded cooperate creb element finding glutathione harel homologue hybrid mammalian potentiated pull ramirez robin src sre steroid synergistically transactivations transferase trouche yeast
Tagcloud (Intersection) ?