LOXL4 and AP1M2

Number of citations of the paper that reports this interaction (PMID 21163940)
13

Data Source:
BioGRID (two hybrid)

		LOXL4	AP1M2
Gene Name		lysyl oxidase-like 4	adaptor-related protein complex 1, mu 2 subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane Receptor Complex Extracellular Vesicular Exosome	Golgi Membrane Lysosomal Membrane Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein-lysine 6-oxidase Activity Scavenger Receptor Activity Copper Ion Binding Protein Binding
	Biological Process	Receptor-mediated Endocytosis Oxidation-reduction Process	Protein Targeting Post-Golgi Vesicle-mediated Transport Vesicle Targeting Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus Membrane Organization
Pathways		Collagen formation Crosslinking of collagen fibrils Elastic fibre formation Assembly of collagen fibrils and other multimeric structures	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Golgi Associated Vesicle Biogenesis The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression Clathrin derived vesicle budding Lysosome Vesicle Biogenesis MHC class II antigen presentation trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AP1M2 APOE CDC37 COL2A1 ECSIT EXOC6 KDM1A LONP1 MAST1 PRMT6 RAD23A RNF32 SUV39H1 TRIP13	20 interactors: A2M AP1B1 AP1G1 AP1M1 AP1S1 AP2B1 APP BLMH ECSIT EHD2 GAK LDLR LOXL4 MAST1 NDRG1 PSEN1 PVR RAB3A RAB3D TGOLN2
Entrez ID		84171	10053
HPRD ID		09538	06296
Ensembl ID		ENSG00000138131	ENSG00000129354
Uniprot IDs		Q96JB6	Q9Y6Q5
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Protein Metabolic Process Cellular Response To Stress Response To Stress Viral Process Developmental Process Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Cellular Protein Metabolic Process Regulation Of Oxidoreductase Activity Cellular Response To DNA Damage Stimulus Cell Differentiation Regulation Of Metabolic Process Histone H3-R2 Methylation Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Histone Modification Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Chromosome Organization Cell Development DNA Metabolic Process Histone Methylation Response To Stimulus Cellular Response To Stimulus Protein Localization Cellular Metabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Regulation Of Presynaptic Membrane Organization Establishment Of Localization In Cell Maintenance Of Location In Cell Negative Regulation Of Dendritic Spine Development High-density Lipoprotein Particle Clearance Axon Development	Vesicle-mediated Transport Regulation Of Defense Response To Virus By Virus Establishment Of Localization In Cell Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Endocytosis Antigen Processing And Presentation Of Peptide Antigen Cellular Localization Intracellular Transport Antigen Processing And Presentation Viral Process Intracellular Protein Transport Cellular Protein Localization Protein Transport Protein Localization Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Post-Golgi Vesicle-mediated Transport Transport Immune System Process Regulation Of Immune System Process Response To External Stimulus Regulation Of Regulated Secretory Pathway Exocytosis Receptor-mediated Endocytosis Synaptic Vesicle Exocytosis Response To Stimulus Positive Regulation Of Exocytosis Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Pigment Accumulation Regulation Of ERBB Signaling Pathway Membrane Organization Secretion By Cell Golgi Vesicle Transport Neurotransmitter Secretion Synaptic Vesicle Transport Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Establishment Of Organelle Localization Secretion Positive Regulation Of Natural Killer Cell Mediated Immunity Melanosome Organization Pigment Granule Organization Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Neurotransmitter Levels
Tagcloud ?		193a 3p bc bladder challenges chemoresistance chemoresistant chemosensitive curative drastically executes forced former formidable genbank guided insight lysyl mechanistic mir multi nr nude obstacle oxidase presents relay reversal xenografts	acaa1 analogous aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		193a 3p bc bladder challenges chemoresistance chemoresistant chemosensitive curative drastically executes forced former formidable genbank guided insight lysyl mechanistic mir multi nr nude obstacle oxidase presents relay reversal xenografts	acaa1 analogous aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppfibp2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?