SPOP and ZBTB16

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SPOP	ZBTB16
Gene Name		speckle-type POZ protein	zinc finger and BTB domain containing 16
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleolus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Double-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Glucose Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesonephros Development Transcription, DNA-templated Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development
Pathways		Hedgehog 'on' state Signaling by Hedgehog	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Conduct disorder (interaction) ( 18846501)
Protein-Protein Interactions		19 interactors: AR BRMS1 DAXX DDIT3 DPPA2 FADD GIT2 H2AFY HCST MYD88 PDX1 PIAS1 RTN3 RXRB SRRM1 TRAF1 TRAF6 UBE2E3 ZBTB16	111 interactors: ACP5 ADAMTS4 AGTR1 AGTR2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BMI1 CASP3 CCDC109B CCDC130 CCDC85B CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COQ6 DLST DNAAF5 DNM2 DPM1 EEF1A1 EIF2S2 ENOX1 EP300 EPN1 ESR1 FAM101B FCHO1 FHL2 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX ICAM3 IL6 KIAA1549 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LSM2 LYAR MAGEA11 MAP3K3 NCOR1 NCOR2 NR3C1 PAFAH1B3 PARP1 PGAM5 PLSCR1 PMAIP1 PML PNRC2 PSMD11 PSMD2 QTRT1 RAB27A RARA RB1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TOLLIP TRAF2 TRIM27 TRIM54 TXNIP UBE2I VDR VTA1 WDR33 ZBTB32 ZNF24 ZNF281
Entrez ID		8405	7704
HPRD ID		16004	11762
Ensembl ID		ENSG00000121067	ENSG00000109906
Uniprot IDs		O43791	Q05516
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z	1BUO 1CS3
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Intracellular Receptor Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Transcription, DNA-templated Androgen Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Transcription From RNA Polymerase II Promoter JNK Cascade RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Activation	Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Metabolic Process Response To Organic Substance Developmental Process Transcription, DNA-templated Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Metabolic Process System Development Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Histone H4 Deacetylation Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Histone Deacetylation Positive Regulation Of Cellular Protein Metabolic Process Protein Deacetylation Gene Expression RNA Metabolic Process Immune System Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Histone H3 Deacetylation Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Chromatin Organization Biosynthetic Process Histone H3-K9 Modification Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Metabolic Process
Tagcloud ?		amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections technologies templates tmprrs2 unstained yielded	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Difference) ?		amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections technologies templates tmprrs2 unstained yielded	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Intersection) ?