TMEM120A and VKORC1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		TMEM120A	VKORC1
Gene Name		transmembrane protein 120A	vitamin K epoxide reductase complex, subunit 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Biological_process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development
Pathways			Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs			Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS			Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		4 interactors: GOT1 PAXIP1 PPP1CC VKORC1	80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB
Entrez ID		83862	79001
HPRD ID		15543	10540
Ensembl ID			ENSG00000167397
Uniprot IDs		Q9BXJ8	Q9BQB6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H3-K36 Methylation Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Fumarate Metabolic Process Glycerol Biosynthetic Process Cellular Carbohydrate Metabolic Process Aspartate Catabolic Process Glutamate Catabolic Process Vitamin K Metabolic Process Aspartate Metabolic Process Chorion Development L-methionine Biosynthetic Process From Methylthioadenosine L-methionine Salvage Response To Radiation Dicarboxylic Acid Catabolic Process Peptidyl-glutamic Acid Carboxylation Fatty Acid Homeostasis Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Methionine Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Initiation Methionine Metabolic Process Triglyceride Catabolic Process Small Molecule Metabolic Process Positive Regulation Of Histone Acetylation Sulfur Amino Acid Biosynthetic Process Regulation Of DNA-templated Transcription, Initiation Entrainment Of Circadian Clock By Photoperiod Regulation Of Histone H3-K4 Methylation Glutamate Metabolic Process Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Isotype Switching Positive Regulation Of Protein Acetylation Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Polyamine Metabolic Process Glycerol Metabolic Process Histone H3-K4 Methylation Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Quinone Metabolic Process Adipose Tissue Development Positive Regulation Of Histone Methylation Drug Metabolic Process Positive Regulation Of Immunoglobulin Production Sulfur Amino Acid Metabolic Process	Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport
Tagcloud ?			arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Difference) ?			arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Intersection) ?