AXIN1 and DVL2

Number of citations of the paper that reports this interaction (PMID 10829020)
10

Data Source:
HPRD (in vivo)

		AXIN1	DVL2
Gene Name		axin 1	dishevelled segment polarity protein 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Microtubule Cell Cortex Postsynaptic Density Cytoplasmic Membrane-bounded Vesicle Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	P53 Binding Signal Transducer Activity GTPase Activator Activity Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Enzyme Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity Ubiquitin Protein Ligase Binding Protein Complex Scaffold Identical Protein Binding Protein Homodimerization Activity Protein Self-association SMAD Binding Armadillo Repeat Domain Binding I-SMAD Binding R-SMAD Binding	Frizzled Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association
	Biological Process	Protein Polyubiquitination In Utero Embryonic Development Optic Placode Formation Positive Regulation Of Protein Phosphorylation Nucleocytoplasmic Transport Apoptotic Process Activation Of JUN Kinase Activity Determination Of Left/right Symmetry Sensory Perception Of Sound Cell Death Dorsal/ventral Axis Specification Positive Regulation Of Peptidyl-threonine Phosphorylation Forebrain Anterior/posterior Pattern Specification Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Olfactory Placode Formation Cytoplasmic Microtubule Organization Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Catenin Import Into Nucleus Post-anal Tail Morphogenesis Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Cellular Protein Complex Assembly Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Embryonic Eye Morphogenesis Axial Mesoderm Formation Negative Regulation Of Protein Metabolic Process Protein Homooligomerization Positive Regulation Of Ubiquitin-protein Transferase Activity Muscle Cell Development Canonical Wnt Signaling Pathway Embryonic Skeletal Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Cellular Response To Organic Cyclic Compound Genetic Imprinting Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Segment Specification Heart Development Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling degradation of AXIN Signaling by WNT in cancer	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL Signaling by Hippo TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by WNT in cancer PCP/CE pathway
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		43 interactors: AMER1 ANP32A APC BTRC CARM1 CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 GAK GNAS GSK3B JUP LMO2 LRP5 LRP6 MAP3K4 MYC MYOT NCK2 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 RNF111 RUNX2 SENP2 SH3GL1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 UTP14A	61 interactors: AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DDI1 DPPA2 DYNLT1 ENKD1 FZD4 GABARAP GABARAPL1 ITCH LRRK2 MAP1LC3A MCRS1 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PRKCA PRKCB PRKCG PRPF3 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 SMURF1 SNF8 SNIP1 SORBS3 TCEB3B THAP1 TIFA TP53 TRAF2 U2AF2 USP5 VANGL1 VHL ZBTB8A ZNF165 ZNF250 ZNF263
Entrez ID		8312	1856
HPRD ID		04819	03690
Ensembl ID		ENSG00000103126	ENSG00000004975
Uniprot IDs		O15169	I3L2N2 O14641
PDB IDs		1DK8 1EMU 1O9U 3ZDI 4B7T	2REY 3CBX 3CBY 3CBZ 3CC0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Regulation Of Signaling Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Signaling Cell Communication Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Signaling Response To Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Gene Expression Canonical Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Tissue Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Metabolic Process Organ Morphogenesis Anatomical Structure Development System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Developmental Process Organ Development Multicellular Organismal Development Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Activation Cellular Metabolic Process Regulation Of Cellular Process Cell Death Death Cellular Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Catabolic Process Negative Regulation Of Signaling Programmed Cell Death Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Membrane Organization Positive Regulation Of Protein Metabolic Process Viral Process Histone H3-T6 Phosphorylation Response To Transforming Growth Factor Beta
Tagcloud ?		aberrations applying arid2 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Difference) ?		aberrations applying arid2 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Intersection) ?