PICALM and EHD2

Number of citations of the paper that reports this interaction (PMID 15182197)
12

Data Source:
HPRD (in vitro, in vivo)

		PICALM	EHD2
Gene Name		phosphatidylinositol binding clathrin assembly protein	EH-domain containing 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Coated Pit Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Vesicle Presynaptic Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neurofibrillary Tangle	Nucleus Plasma Membrane Caveola Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Clathrin Binding Clathrin Heavy Chain Binding Clathrin Adaptor Activity	Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Hydrolase Activity Protein Domain Specific Binding
	Biological Process	Protein Complex Assembly Receptor-mediated Endocytosis Axonogenesis Cell Proliferation Negative Regulation Of Gene Expression Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Cargo Loading Into Vesicle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Iron Ion Homeostasis Clathrin-mediated Endocytosis Iron Ion Import Into Cell Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process	Endocytosis Blood Coagulation Metabolic Process Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Positive Regulation Of Endocytic Recycling
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 19734902 21627779) Alzheimer's disease (late onset) ( 21460841) Tourette syndrome ( 22889924)
Protein-Protein Interactions		10 interactors: AP2A1 CASP3 CASP8 CLTC CLTCL1 DDIT3 EHD2 ITSN1 PELI2 PLCG1	13 interactors: AP1M1 AP1M2 AP2M1 BPGM DDX56 EHBP1 PICALM PICK1 RBSN SLC2A4 SPATA24 TAGLN2 TBC1D23
Entrez ID		8301	30846
HPRD ID		04320	10434
Ensembl ID		ENSG00000073921	ENSG00000024422
Uniprot IDs		Q13492	Q9NZN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vesicle-mediated Transport Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Transport Cell Morphogenesis Involved In Differentiation Cellular Localization Anatomical Structure Morphogenesis Signal Transduction Positive Regulation Of Transport Regulation Of Phosphorus Metabolic Process Regulation Of Neuron Death Intracellular Transport Response To Organic Substance Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Intracellular Signal Transduction Signaling Positive Regulation Of Neuron Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Phosphorylation Cell Communication Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Receptor-mediated Endocytosis Execution Phase Of Apoptosis Positive Regulation Of Neuron Death Negative Regulation Of Determination Of Dorsal Identity	Regulation Of Defense Response To Virus By Virus Membrane Organization Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cell Differentiation Clathrin-mediated Endocytosis Antigen Processing And Presentation Of Peptide Antigen Golgi Vesicle Transport Vesicle-mediated Transport Antigen Processing And Presentation Intracellular Transport Amylopectin Biosynthetic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Intracellular Protein Transport Developmental Process Post-Golgi Vesicle-mediated Transport Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Establishment Of Localization In Cell Viral Process Immune System Process Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Synaptic Transmission Cellular Protein Localization Cargo Loading Into Vesicle Protein Transport Cellular Localization Iron Ion Import Into Cell Establishment Of Protein Localization Regulation Of Endocytosis DNA Methylation Involved In Embryo Development Establishment Of Vesicle Localization Vesicle Organization Pigment Granule Maturation Endosome To Melanosome Transport Glucose Import Endosomal Transport Vesicle Localization Dendritic Spine Maintenance Cellular Pigment Accumulation Synaptic Vesicle Maturation Positive Regulation Of Beta-amyloid Formation Neuronal Ion Channel Clustering Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Iron Ion Import Negative Regulation Of Actin Nucleation
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 enrichment fhl2 homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely	acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 enrichment fhl2 homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Intersection) ?