HIST3H3 and ERAP1

Number of citations of the paper that reports this interaction (PMID 23281010)
0

Data Source:
BioGRID (unspecified method)

		HIST3H3	ERAP1
Gene Name		histone cluster 3, H3	endoplasmic reticulum aminopeptidase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Metalloexopeptidase Activity Zinc Ion Binding
	Biological Process	Telomere Maintenance	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Membrane Protein Ectodomain Proteolysis Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis
Pathways		DNA Damage/Telomere Stress Induced Senescence Meiotic recombination Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Mitotic Prophase formation of the beta-catenin:TCF transactivating complex Cellular Senescence Meiotic synapsis Signaling by Wnt Cell Cycle, Mitotic M Phase Telomere Maintenance Packaging Of Telomere Ends TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prophase Chromosomes	Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Adaptive Immune System
Drugs
Diseases
GWAS			Alcohol dependence ( 19581569) Ankylosing spondylitis ( 21743469 20062062) Behcet's disease ( 23291587) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190)
Protein-Protein Interactions		183 interactors: ADNP AFF1 AHDC1 ANP32A ASF1A ASH2L ATAD2 AURKA AURKB BIRC5 BMI1 BPTF BRD7 C11orf30 C17orf49 CBX1 CBX2 CBX3 CBX4 CBX5 CBX7 CBX8 CCDC101 CDYL CDYL2 CHAF1A CHAF1B CHAMP1 CHD1 CHD4 CHD6 CHUK CREBBP CTBP1 CTBP2 DEK DIDO1 DOT1L DPF2 DPY30 DYRK2 EGFR EHMT1 EHMT2 EP300 ERAP1 EZH2 FOXA1 GADD45A GATAD1 GLYR1 GTF3C4 HAT1 HDAC1 HDAC2 HDAC8 HIRIP3 HMGXB4 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPK HNRNPL HNRNPR ING2 ING4 IRAK1 JADE2 JADE3 JAK1 JAK2 KAT2A KAT2B KAT5 KAT6A KDM1A KDM2A KDM3B KDM5A KDM5D KDM6A KIF2A KIF2C KMT2A KPNA1 LRIF1 LRWD1 MBD3 MCM2 MCM7 MDM2 MEN1 MGA MIER1 MLLT1 MORF4L1 MSL3 MTA1 MTA2 NAP1L4 NCL NCOA2 NCOA3 NOC2L NONO NPM1 NSD1 ORC2 ORC3 ORC4 ORC5 PCGF6 PHC2 PHC3 PHF12 PHF7 PHF8 PIM1 POGZ PPIB PPM1G PRDM2 PRKCA PRKCZ PTBP1 PTMA RAG1 RBBP4 RBBP5 RBBP7 RBP5 RCOR1 RING1 RNF2 RPS6KA3 RPS6KA5 RREB1 SAP30 SET SETD2 SETD7 SETDB1 SFPQ SIN3A SIN3B SMN1 SMNDC1 SMYD3 SUPT20H SUPT3H SUV39H1 SUZ12 TADA1 TADA3 TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1A TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TBP TDRD3 TNPO1 TRPM7 UHRF1 VPRBP WHSC1 ZMYM4 ZNF217 ZNF516	3 interactors: HIST3H3 IL6R TNFRSF1A
Entrez ID		8290	51752
HPRD ID		04156	06015
Ensembl ID		ENSG00000168148	ENSG00000164307
Uniprot IDs		Q16695	Q9NZ08
PDB IDs		2V1D 2YBP 2YBS 3A6N 3T6R	2YD0 3MDJ 3QNF 3RJO
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Modification Chromosome Organization Histone Modification Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Gene Expression Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Peptidyl-amino Acid Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Protein Acetylation Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Regulation Of Cellular Process Metabolic Process Histone H3 Acetylation Histone Lysine Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Peptidyl-lysine Methylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression	Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Regulation Of Interleukin-6 Production Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Bacterium Negative Regulation Of Cytokine Production Regulation Of Peptidyl-tyrosine Phosphorylation Hepatic Immune Response Apoptotic Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Activation Of Janus Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Collagen Biosynthetic Process Inflammatory Response Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Cytokine-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Metabolic Process Response To Bacterium Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Cytokine Production Negative Regulation Of Interleukin-8 Production Interleukin-6-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Monocyte Chemotaxis Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Estradiol Stimulus Neutrophil Mediated Immunity Response To Cytokine Response To Other Organism Positive Regulation Of Protein Phosphorylation Response To Biotic Stimulus Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Positive Regulation Of Intracellular Signal Transduction Cellular Response To Estrogen Stimulus Prostaglandin Metabolic Process Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Phosphorylation Response To Interleukin-6 Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Defense Response To Gram-negative Bacterium Negative Regulation Of Interleukin-6 Production Regulation Of Collagen Metabolic Process Apoptotic Process
Tagcloud ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra innate modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	ad5 adenovirus ag aminopeptidase augmented autoimmune basel behind chemokine endoplasmic genetically herein hpbmcs identifying inflammasome innate internalization investigating karger modulating mononuclear nlrp3 polymorphic pyrin reticulum secreted unexpectedly variants vectors
Tagcloud (Difference) ?		alters annotation ca3 candidate cdh23 dataset disequilibrium ear fdr filtering gwas harbored hypotheses hypothetical icsnpathway il27ra modulates morphogenesis pneumoconiosis ptprz1 rs11592462 rs2230656 rs2292151 rs8120 snps stereocilia strongest ticam1	ad5 adenovirus ag aminopeptidase augmented autoimmune basel behind chemokine endoplasmic genetically herein hpbmcs identifying inflammasome internalization investigating karger modulating mononuclear nlrp3 polymorphic pyrin reticulum secreted unexpectedly variants vectors
Tagcloud (Intersection) ?		innate