CAPN1 and CASP14

Number of citations of the paper that reports this interaction (PMID 12200134)
9

Data Source:
HPRD (in vitro, in vivo)

		CAPN1	CASP14
Gene Name		calpain 1, (mu/I) large subunit	caspase 14, apoptosis-related cysteine peptidase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Keratin Filament Extracellular Vesicular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Cysteine-type Endopeptidase Activity
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization Receptor Catabolic Process	Proteolysis Epidermis Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Keratinization Cornification Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: ACTC1 ACTN2 AES ARF6 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KNG1 LAMTOR1 MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TP53 UFSP2 VIM	8 interactors: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 MEOX2 UCHL5
Entrez ID		823	23581
HPRD ID		00253	05788
Ensembl ID		ENSG00000014216	ENSG00000105141
Uniprot IDs		B2RDI5 B4DWH5 P07384	B2CIS9 P31944
PDB IDs		1ZCM 2ARY
Enriched GO Terms of Interacting Partners?		Apoptotic Process Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Movement Of Cell Or Subcellular Component Response To Stimulus Regulation Of Cell Death Regulation Of Signaling Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Anatomical Structure Development Organ Development Response To Organic Substance Actin-mediated Cell Contraction Cell Differentiation Cell Development Protein Localization To Nucleus Protein Localization To Organelle System Development Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Muscle Contraction Response To External Stimulus Anatomical Structure Morphogenesis Cellular Response To Stimulus Cell Activation Regulation Of Cellular Process Muscle System Process Axon Guidance Positive Regulation Of Transport Blood Coagulation Hemostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Localization Rhythmic Process Platelet Activation Wound Healing Negative Regulation Of Cell Death Positive Regulation Of Cell Death Regulation Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Response To Stress	Execution Phase Of Apoptosis Proteolysis Cell Death Death Cellular Response To Mechanical Stimulus Regulation Of Endopeptidase Activity Apoptotic Process Regulation Of Peptidase Activity Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Regulation Of Apoptotic Process Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Regulation Of Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Apoptotic Signaling Pathway Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Mitochondrial Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Death Regulation Of Signal Transduction TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Peptidase Activity Regulation Of Signaling Luteolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Somite Specification Intracellular Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Response To Stress
Tagcloud ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	abc bcl2af1 bcl2l10 biology casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tnfrsf25 tnfsf8 tunel valuable
Tagcloud (Difference) ?		5k3 alpl armitage beadchip bovinesnp50 bull catsper1 cohran dehygrogenase ethanolamine etnk1 friesian goldenhelix hibadh hydroxyisobutyrate kelch klhl1 loc785875 mc4r pdzrn4 prkcb rs110596818 rs110827324 rs110876480 rs29011704 sire srd5a2 svs7 trim36	abc bcl2af1 bcl2l10 biology casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tnfrsf25 tnfsf8 tunel valuable
Tagcloud (Intersection) ?