CAMK2A and ITGB1BP1

Number of citations of the paper that reports this interaction (PMID 9813144)
12

Data Source:
HPRD (in vitro)

		CAMK2A	ITGB1BP1
Gene Name		calcium/calmodulin-dependent protein kinase II alpha	integrin beta 1 binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane	Ruffle Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Protein Transporter Activity Protein Kinase Binding Protein Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process	Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Protein Transport Cell Migration Cell Differentiation Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cdc42 GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Blood Vessel Size Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway
Pathways		Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB	10 interactors: APP CAMK2A EEF1A1 FAF1 FIGNL1 ITGB1 KRIT1 LRP1 LRP2 LRP8
Entrez ID		815	9270
HPRD ID		06532	06194
Ensembl ID		ENSG00000070808	ENSG00000119185
Uniprot IDs		A8K161 Q7LDD5 Q8IWE0 Q9UQM7	B4DQY5 O14713
PDB IDs		2VZ6 3SOA	1K11 4DX8 4DX9 4JIF
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential	Response To Radiation Response To Abiotic Stimulus Response To Light Stimulus Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Regulation Of Apoptotic Process Detection Of Light Stimulus Regulation Of Cell Death Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Stimulus Endocytosis Steroid Metabolic Process Brain Development Cellular Response To Ionizing Radiation Regulation Of Metabolic Process Head Development Visual Learning Visual Behavior Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Receptor-mediated Endocytosis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ammon Gyrus Development Beta-amyloid Clearance Associative Learning Response To External Stimulus Central Nervous System Development Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cell Death Developmental Cell Growth Negative Regulation Of Intracellular Signal Transduction Blood Vessel Morphogenesis Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Forebrain Development Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Signaling Blood Vessel Development Cholesterol Metabolic Process
Tagcloud ?		acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Difference) ?		acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Intersection) ?