SEMA6D and PLXNA1

Number of citations of the paper that reports this interaction (PMID 14977921)
72

Data Source:
HPRD (in vivo)

		SEMA6D	PLXNA1
Gene Name		sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	plexin A1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Semaphorin Receptor Complex Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Semaphorin Receptor Binding	Receptor Activity Semaphorin Receptor Activity
	Biological Process	Axon Guidance Positive Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Smooth Muscle Cell Migration Ventricular System Development	Multicellular Organismal Development Axon Guidance Regulation Of Smooth Muscle Cell Migration Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway
Pathways		Axon guidance Semaphorin interactions Other semaphorin interactions	Axon guidance Semaphorin interactions Other semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Eating disorders ( 22911880)	MRI atrophy measures ( 21116278)
Protein-Protein Interactions		1 interactors: PLXNA1	7 interactors: AKT1 FES NRP1 PLXNB1 RHOD RND1 SEMA6D
Entrez ID		80031	5361
HPRD ID		10221	11868
Ensembl ID		ENSG00000137872	ENSG00000114554
Uniprot IDs		A6NM95 Q8NFY4	Q9UIW2
PDB IDs
Enriched GO Terms of Interacting Partners?		Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Branching Involved In Salivary Gland Morphogenesis Regulation Of Smooth Muscle Cell Migration Semaphorin-plexin Signaling Pathway Salivary Gland Morphogenesis Salivary Gland Development Exocrine System Development Gland Morphogenesis	Cell Projection Organization Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Neuron Projection Morphogenesis Regulation Of Locomotion Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Generation Of Neurons Neurogenesis Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Cell Migration Cell Part Morphogenesis Positive Regulation Of Cell Motility Cell Development Response To External Stimulus Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Neuron Development Regulation Of Neuron Projection Development Cell Morphogenesis Negative Regulation Of Osteoblast Proliferation Neuron Differentiation Nervous System Development Regulation Of Cell Projection Organization Locomotion Regulation Of Neuron Differentiation Regulation Of Cell Migration Movement Of Cell Or Subcellular Component Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Osteoblast Proliferation Regulation Of Neurogenesis Positive Regulation Of Neuron Projection Development Semaphorin-plexin Signaling Pathway Regulation Of Cell Development Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Projection Organization Cell Differentiation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Smooth Muscle Cell Migration Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation
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