WLS and OPRM1

Number of citations of the paper that reports this interaction (PMID 23840749)
1

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		WLS	OPRM1
Gene Name		wntless Wnt ligand secretion mediator	opioid receptor, mu 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Dendrite Membrane Dendrite Cytoplasm	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Dendrite Membrane Dendrite Cytoplasm Sarcolemma Neuron Projection Perikaryon Membrane Raft
	Molecular Function	Signal Transducer Activity Protein Binding Wnt-protein Binding Mu-type Opioid Receptor Binding	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Beta-endorphin Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding Protein Domain Specific Binding Filamin Binding G-protein Beta-subunit Binding Morphine Receptor Activity Neuropeptide Binding
	Biological Process	Mesoderm Formation Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Canonical Wnt Signaling Pathway	Acute Inflammatory Response To Antigenic Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Locomotory Behavior Negative Regulation Of Cell Proliferation Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Food Positive Regulation Of Appetite Response To Lipopolysaccharide Cellular Response To Stress Wound Healing Response To Cocaine Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Response To Growth Factor Cellular Response To Morphine Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G-protein activation Class A/1 (Rhodopsin-like receptors) Opioid Signalling G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Tramadol Morphine Codeine Hydromorphone Methadone Oxycodone Levallorphan Butorphanol Propoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Levomethadyl Acetate Methadyl Acetate 3-Methylthiofentanyl Dimethylthiambutene Heroin Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl Tapentadol Alvimopan Methylnaltrexone
Diseases
GWAS		Bone mineral density ( 22504420)	Coronary heart disease ( 21347282)
Protein-Protein Interactions		1 interactors: OPRM1	23 interactors: ADRBK2 CALM1 COPS5 DNAJB4 DOK4 DOK5 FLNA GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 KCNF1 OPRD1 PLD2 PPL RANBP9 SIAH1 SIAH2 UBC VAPA WLS ZYX
Entrez ID		79971	4988
HPRD ID		10980	02484
Ensembl ID		ENSG00000116729	ENSG00000112038
Uniprot IDs		Q5T9L3	P35372
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Wnt Protein Secretion Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Cellular Response To Morphine Positive Regulation Of Appetite Cellular Response To Isoquinoline Alkaloid Negative Regulation Of CAMP-mediated Signaling Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cytosolic Calcium Ion Concentration Opioid Receptor Signaling Pathway Behavioral Response To Ethanol Positive Regulation Of CAMP-mediated Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Response To Food Cellular Response To Ammonium Ion Regulation Of Appetite Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP-mediated Signaling Response To Food Negative Regulation Of Lyase Activity Regulation Of Sensory Perception Of Pain Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Inflammatory Response To Antigenic Stimulus Dopamine Receptor Signaling Pathway Cellular Response To Alkaloid Negative Regulation Of Nucleotide Metabolic Process Response To Morphine Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Cocaine Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Excitatory Postsynaptic Membrane Potential Acute Inflammatory Response Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Neuropeptide Signaling Pathway Response To Ammonium Ion	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Platelet Activation Signal Transduction Regulation Of Signal Transduction Response To Stimulus Dopamine Receptor Signaling Pathway Regulation Of Signaling Synaptic Transmission Cell-cell Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Calcium Ion Transport Cellular Response To Stimulus Blood Coagulation Hemostasis Establishment Of Localization In Cell Regulation Of I-kappaB Kinase/NF-kappaB Signaling Receptor Metabolic Process G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Cellular Localization Regulation Of Cellular Process Regulation Of Ion Transport Vesicle-mediated Transport Cell Activation Cytoplasmic Transport Response To Wounding Cell Projection Organization Negative Regulation Of Signaling Response To Stress Negative Regulation Of Calcium Ion Transport Receptor Internalization Transport Nervous System Development Neuron Projection Development Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Endosomal Transport Membrane Organization Cellular Process Activation Of Phospholipase C Activity
Tagcloud ?			13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?			13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?