SRD5A3 and ADK

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SRD5A3	ADK
Gene Name		steroid 5 alpha-reductase 3	adenosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Cholestenone 5-alpha-reductase Activity	Adenosine Kinase Activity ATP Binding Phosphotransferase Activity, Alcohol Group As Acceptor Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Androgen Biosynthetic Process Steroid Metabolic Process Polyprenol Catabolic Process Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Purine Nucleobase Metabolic Process DATP Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Phosphorylation Circadian Regulation Of Gene Expression Positive Regulation Of T Cell Proliferation Purine-containing Compound Salvage AMP Salvage Small Molecule Metabolic Process Type B Pancreatic Cell Proliferation Adenosine Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Androgen biosynthesis Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Metabolism of steroid hormones and vitamin D Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins	Purine metabolism Metabolism of nucleotides Purine salvage
Drugs
Diseases
GWAS			Permanent tooth development ( 21931568) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328)
Protein-Protein Interactions		2 interactors: ADK NUDT15	2 interactors: FICD SRD5A3
Entrez ID		79644	132
HPRD ID		07825	00039
Ensembl ID		ENSG00000128039	ENSG00000156110
Uniprot IDs		Q9H8P0	P55263
PDB IDs			1BX4 2I6A 2I6B
Enriched GO Terms of Interacting Partners?		Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Metabolic Process DATP Biosynthetic Process AMP Salvage Purine Nucleotide Metabolic Process DGTP Catabolic Process DGTP Metabolic Process Nucleobase-containing Small Molecule Catabolic Process AMP Biosynthetic Process Purine Ribonucleoside Salvage Nucleotide Metabolic Process Deoxyribonucleoside Triphosphate Catabolic Process DATP Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nucleoside Triphosphate Catabolic Process Type B Pancreatic Cell Proliferation Adenosine Metabolic Process Deoxyribonucleotide Biosynthetic Process AMP Metabolic Process Purine Nucleotide Salvage Deoxyribose Phosphate Catabolic Process Positive Regulation Of Cardiac Muscle Hypertrophy Organophosphate Metabolic Process Purine-containing Compound Salvage Deoxyribonucleotide Catabolic Process Regulation Of Cardiac Muscle Hypertrophy Purine Nucleotide Catabolic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process Nucleotide Catabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of T Cell Proliferation Nucleoside Triphosphate Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Small Molecule Metabolic Process Regulation Of T Cell Proliferation Organophosphate Catabolic Process Purine Nucleotide Biosynthetic Process Circadian Rhythm Ribose Phosphate Biosynthetic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Purine Nucleoside Metabolic Process Regulation Of T Cell Activation Ribonucleotide Metabolic Process	Polyprenol Catabolic Process Protein Adenylylation Dolichol Metabolic Process Dolichyl Diphosphate Biosynthetic Process Negative Regulation Of Rho GTPase Activity Androgen Biosynthetic Process Negative Regulation Of Ras GTPase Activity Negative Regulation Of GTPase Activity Androgen Metabolic Process Alcohol Catabolic Process Hormone Biosynthetic Process Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Steroid Biosynthetic Process Protein N-linked Glycosylation Isoprenoid Metabolic Process Cellular Lipid Catabolic Process
Tagcloud ?			adenylate aminopeptidase bs coordinating differs if1 l14 l15 l16 l17 l18 l24 l29 l30 l36 l5 l6 operons principally psecy s10 s11 s13 s14 s17 s5 secy spc subtilis
Tagcloud (Difference) ?			adenylate aminopeptidase bs coordinating differs if1 l14 l15 l16 l17 l18 l24 l29 l30 l36 l5 l6 operons principally psecy s10 s11 s13 s14 s17 s5 secy spc subtilis
Tagcloud (Intersection) ?