CACNA1A and SCP2

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		CACNA1A	SCP2
Gene Name		calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	sterol carrier protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Dendrite Cell Projection Neuronal Cell Body	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Membrane Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	Fatty-acyl-CoA Binding Receptor Binding Protein Binding Phosphatidylinositol Transporter Activity Cholesterol Binding Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Oleic Acid Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Glucose Metabolic Process Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Neuromuscular Synaptic Transmission Synapse Assembly Adult Walking Behavior Cell Death Gamma-aminobutyric Acid Secretion Regulation Of Acetylcholine Secretion, Neurotransmission Cell Growth Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Transmission Of Nerve Impulse Spinal Cord Motor Neuron Differentiation Cerebellum Maturation Cerebellar Molecular Layer Development Cerebellar Purkinje Cell Differentiation Vestibular Nucleus Development Cellular Chloride Ion Homeostasis Negative Regulation Of Hormone Biosynthetic Process Regulation Of Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Neurotransmitter Metabolic Process Hormone Metabolic Process Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Behavioral Response To Pain Calcium Ion-dependent Exocytosis Of Neurotransmitter Dendrite Morphogenesis Regulation Of Axonogenesis Regulation Of Insulin Secretion Musculoskeletal Movement, Spinal Reflex Action Neuromuscular Process Controlling Balance Membrane Depolarization Rhythmic Synaptic Transmission Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Steroid Biosynthetic Process Bile Acid Biosynthetic Process Progesterone Biosynthetic Process Lipid Transport Peroxisome Organization Bile Acid Metabolic Process Phospholipid Transport Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Protein Localization To Plasma Membrane Lipid Hydroperoxide Transport
Pathways		Integration of energy metabolism Regulation of insulin secretion Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses	Metabolism of lipids and lipoproteins alpha-linolenic acid (ALA) metabolism alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Drugs		Pregabalin Verapamil Loperamide Bepridil
Diseases
GWAS
Protein-Protein Interactions		92 interactors: ABCA2 ABI1 ACTN1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 ASNA1 BTG3 BZRAP1 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LPHN1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TUBB2B UQCRC2 VARS VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	8 interactors: ACAA2 ACOX1 CACNA1A CAV1 EHHADH PEX5 PITPNA TRIP13
Entrez ID		773	6342
HPRD ID		03004	01700
Ensembl ID		ENSG00000141837	ENSG00000116171
Uniprot IDs		B5TYJ1 O00555 Q9NS89	B2R761 E9PLD1 P22307 Q59HG9
PDB IDs		3BXK	1QND 2C0L
Enriched GO Terms of Interacting Partners?		Secretion By Cell Secretion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Voltage-gated Calcium Channel Activity Detection Of Visible Light Enzyme Linked Receptor Protein Signaling Pathway Detection Of Light Stimulus Multicellular Organismal Development Phototransduction, Visible Light Anatomical Structure Development Cellular Localization Axon Development Developmental Process Establishment Of Localization In Cell Phototransduction Regulation Of Cellular Process System Development Axonogenesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Detection Of Abiotic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Degranulation Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Regulation Of Cation Channel Activity Axon Guidance Nervous System Development Detection Of Calcium Ion Regulation Of Intracellular Cholesterol Transport Regulation Of Cell Communication By Electrical Coupling Neuron Projection Morphogenesis Exocytosis Neuron Projection Development Cellular Response To Growth Factor Stimulus Neuron Differentiation Inositol Phosphate Metabolic Process Cell Projection Morphogenesis Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Cell Part Morphogenesis Response To Growth Factor Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Platelet Activation Cell-cell Signaling Nerve Growth Factor Processing Pathogenesis Neurotrophin TRK Receptor Signaling Pathway	Fatty Acid Beta-oxidation Lipid Metabolic Process Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Metabolic Process Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cellular Lipid Catabolic Process Organic Acid Metabolic Process Monocarboxylic Acid Metabolic Process Small Molecule Metabolic Process Lipid Modification Carboxylic Acid Catabolic Process Very Long-chain Fatty Acid Metabolic Process Lipid Catabolic Process Peroxisome Organization Membrane Organization Mitochondrial Membrane Organization Protein Localization To Membrane Cerebellar Molecular Layer Development Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Oxygen Levels Lipid Homeostasis Membrane Depolarization Vestibular Nucleus Development Negative Regulation Of Protein Homotetramerization Nitric Oxide Homeostasis Neuromuscular Process Oxidation-reduction Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Protein Import Into Peroxisome Matrix, Translocation Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Cholesterol Homeostasis Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Gamma-aminobutyric Acid Secretion Negative Regulation Of Pinocytosis Caveolin-mediated Endocytosis Protein Localization To Basolateral Plasma Membrane Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Acetylcholine Secretion, Neurotransmission Mammary Gland Involution Organelle Organization Cytosolic Calcium Ion Homeostasis
Tagcloud ?		acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage	cannabinoid cannabinoids cb chemotactic chemotaxis clone confocal crosstalk cxcl12 cxcr4 cytoskeletal elucidation healing innovative jwh mcf7 metastasis mmtv modulate nt orthotopic p42 p44 possess psychoactive pymt syngenic tumorigenic wound
Tagcloud (Difference) ?		acetazolamide ataxia attacks autosomal causative causing coincidence confutes defect dysarthria dystonia ea ea2 encodes episodes episodic gait gated heterogeneous inherited migraine mim nonsense oculomotor paroxysmal q varied voltage	cannabinoid cannabinoids cb chemotactic chemotaxis clone confocal crosstalk cxcl12 cxcr4 cytoskeletal elucidation healing innovative jwh mcf7 metastasis mmtv modulate nt orthotopic p42 p44 possess psychoactive pymt syngenic tumorigenic wound
Tagcloud (Intersection) ?