YWHAZ and FOXO3

Number of citations of the paper that reports this interaction (PMID 10102273)
1099

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		YWHAZ	FOXO3
Gene Name		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	forkhead box O3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Focal Adhesion Postsynaptic Density Cytoplasmic Vesicle Membrane Cell Leading Edge Melanosome Mast Cell Granule Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Domain Specific Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Binding Transcription Cofactor Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	Histamine Secretion By Mast Cell Protein Targeting To Mitochondrion Apoptotic Process Signal Transduction Blood Coagulation Gene Expression Platelet Activation Response To Drug Negative Regulation Of Apoptotic Process Establishment Of Golgi Localization Membrane Organization Golgi Reassembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovulation From Ovarian Follicle Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Oocyte Maturation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Translation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Cellular Response To Oxidative Stress Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Signaling by Wnt deactivation of the beta-catenin transactivating complex Rap1 signalling RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytokine Signaling in Immune system Activation of BAD and translocation to mitochondria Signaling by Interleukins TCF dependent signaling in response to WNT KSRP destabilizes mRNA GP1b-IX-V activation signalling Signaling by WNT in cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Signaling by NODAL Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430)	Insulin-like growth factors ( 21216879) Normalized brain volume ( 19010793) Prostate cancer ( 23535732)
Protein-Protein Interactions		191 interactors: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARAF ARHGEF2 ATP5A1 ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CFL1 CGNL1 CLIC4 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EPB41L1 EPB41L2 EPB41L3 EXO1 FAM13B FAM53C FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 HDAC4 HDAC9 HIST1H3A HIVEP2 HMGN1 HSPA1A HSPA1B IGF1R IL9R ING1 INPP5A IRS1 IRS2 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIAA1377 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LCP2 LIMK1 LRMP LYST MADD MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PRDX2 PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RFWD2 RGS3 RIN1 RMDN3 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNX24 SORBS2 SQSTM1 SSFA2 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YWHAE ZAK ZNF839	24 interactors: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBB2IP ESR1 FOXG1 IKBKB MAPK1 MAPK6 NR1H2 NR1H3 SGK1 SIRT1 SMAD2 SMAD3 SMAD4 UBC VDR YWHAG YWHAZ
Entrez ID		7534	2309
HPRD ID		03183	04061
Ensembl ID		ENSG00000164924	ENSG00000118689
Uniprot IDs		D0PNI1 P63104	B4DVZ6 O43524
PDB IDs		1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL	2K86 2LQH 2LQI 2UZK
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Signal Transduction Regulation Of Kinase Activity Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Response To Stress Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction Protein Phosphorylation Neurotrophin Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Organic Substance Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Death Regulation Of MAPK Cascade Apoptotic Process Cell Death Death Programmed Cell Death Positive Regulation Of Protein Modification Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Innate Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization	Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction DNA-templated Transcription, Initiation Signaling Response To Organic Substance Regulation Of Gene Expression Cellular Response To Stimulus Cell Communication Epithelium Development Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Mammary Gland Epithelium Development Intracellular Receptor Signaling Pathway Positive Regulation Of Transport Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Cyclic Compound Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mammary Gland Epithelial Cell Proliferation Response To Organic Cyclic Compound Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Stimulus Response To Hypoxia Apoptotic Process Mammary Gland Development Regulation Of Immune System Process Gland Development Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation infiltrating let lungs mir mirna orchestrating participating pertaining poisoning ptgs2 runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Difference) ?		actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2	20b 34a 7e actively ccnd ccne1 compromised dysregulated enterotoxin exacerbation infiltrating let lungs mir mirna orchestrating participating pertaining poisoning ptgs2 runx1 saw seb silico smad3 staphyloccocal stringent tbx21 tgfb
Tagcloud (Intersection) ?